文献类型： 外文期刊
作者： Yang, Yang 1 ; Mei, Wen-Li 2 ; Kong, Fan-Dong 2 ; Chen, Hui-Qin 2 ; Li, Wei 2 ; Chen, Zhi-Bao 1 ; Dai, Hao-Fu 2 ;
作者机构： 1.Heilongjiang Bayi Agr Univ, Coll Life Sci & Technol, 5 Xinfeng Rd, Daqing 163319, Heilongjiang, Peoples R China
2.Chinese Acad Trop Agr Sci, Key Lab Biol & Genet Resources Trop Crops, Minist Agr, Inst Trop Biosci & Biotechnol, Haikou 571101, Hainan, Peoples R China
关键词： Aquilaria crassna;Agarwood;Bi-2-(2-phenylethyl)chromone;Biological activity
期刊名称：FITOTERAPIA （ 影响因子：2.882； 五年影响因子：3.202 ）
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收录情况： SCI
摘要： Four new bi-2-(2-phenylethyl)chromone derivatives, crassins A-D (1-4), were isolated from the EtOAc extract of agarwood originating from Aquilaria crassna. The structures including the absolute configurations of compounds were unambiguously elucidated by extensive spectroscopic methods (1D and 2D NMR, UV, ECD, IR, MS), and by comparison with the literature. The isolated compounds were tested for their acetylcholinesterase (AChE) and alpha-glucosidase inhibitory activities, as well as cytotoxic activities. All the compounds showed weak inhibitory activity against AChE, while compounds 3 and 4 also displayed weak cytotoxicity against human myeloid leukemia cell line (K562). (C) 2017 Published by Elsevier B.V.
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