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Four new bi-phenylethylchromones from artificial agarwood

文献类型： 外文期刊

作者： Xiang, Pan; Mei, Wenli 1 ; Chen, Huiqin 1 ; Kong, Fandong 1 ; Wang, Hao 1 ; Liao, Ge 1 ; Zhou, Liman 1 ; Dai, Haofu 2 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Minist Agr, Key Lab Biol & Genet Resources Trop Crops, Haikou 571101, Hainan, Peoples R China

2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Minist Agr, Key Lab Biol & Genet Resources Trop

关键词： Bi-2-(2-phenylethypehromone;Agarwood;Aquilaria sinensis;Circular dichroism (CD);AChE inhibitory activity;alpha-Glucosidase inhibitory activity

期刊名称：FITOTERAPIA （ 影响因子：2.882； 五年影响因子：3.202 ）

ISSN：

年卷期：

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收录情况： SCI

摘要： Four new bi-phenylethylchromones (1-4) were isolated from the EtOAc extract of artificial agarwood induced by holing method originating from Aquilaria sinensis (Lour.) Gilg. The structures of new compounds were unambiguously elucidated by one- and two-dimensional NMR and HRESIMS measurements, and the absolute configuration was determined by analysis of circular dichroism (CD) spectra. All compounds were tested for acetylcholinesterase (AChE) inhibitory activity using modified Ellman's colorimetric method and alpha-glucosidase inhibitory activity using PNPG method. Compounds 2-4 exhibited different levels of inhibitory activity against AChE with the inhibition ratios in the range of 10-45%. However, none of the compounds was active against the alpha-glucosidase.

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