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Characterization and Immunomodulatory Activity of a Novel Peptide, ECFSTA, from Wheat Germ Globulin

文献类型： 外文期刊

作者： Wu, Wenjia 1 ; Zhang, Mengmeng 1 ; Ren, Yao 2 ; Cai, Xinze 1 ; Yin, Zhina 1 ; Zhang, Xiaoai 3 ; Min, Tian 1 ; Wu, Hui 1 ;

作者机构： 1.South China Univ Technol, Coll Food Sci & Engn, Guangzhou 510640, Guangdong, Peoples R China

2.Sichuan Univ, Coll Light Ind Text & Food Engn, Chengdu 610065, Sichuan, Peoples R China

3.Guangdong Acad Agr Sci, Guangzhou 510640, Guangdong, Peoples R China

关键词： wheat germ globulin;peptide sequence;immunomodulatmy activity;signal transduction pathways

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：5.279； 五年影响因子：5.269 ）

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收录情况： SCI

摘要： A novel peptide was extracted from wheat germ globulin and purified using ion-exchange chromatography, gel filtration chromatography, and semi-preparative reversed-phase high-performance liquid chromatography (RP-HPLC). The sequence of the peptide was found to be Glu-Cys-Phe-Ser-Thr-Ala (ECFSTA). Its immunomodulatory effects were evaluated, and the results showed that ECFSTA could enhance phagocytosis of RAW 264.7 cells and significantly increase their secretion of nitric oxide (NO), interleukin 6 (IL-6), tumor necrosis factor a (TNF-alpha), and reactive oxygen species (ROS). ECFSTA activated macrophages mainly through the pattern recognition receptors (PRRs) of toll-like receptor 2 (TLR2) and toll-like receptor 4 (TLR4), and the production of ROS simultaneously stimulated macrophages to produce TNF-a. Thus, ECFSTA could be used as an immunomodulator and might be a promising component of functional foods.

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