文献类型： 外文期刊
作者：
Ren, Hongyan
1
;
Tao, Cong
2
;
Li, Kui
2
;
Bi, Yanzhen
1
;
Zheng, Xinmin
1
;
作者机构： 1.Hubei Acad Agr Sci, Inst Vet & Anim Sci, Key Lab Anim Embryo & Mol Breeding Hubei Prov, Wuhan 430064, Peoples R China
2.Chinese Acad Agr Sci, Inst Anim Sci, State Key Lab Anim Nutr, Beijing 100193, Peoples R China
关键词： MicroRNA-200s;Gene targeting;Cre-loxp
期刊名称：APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY （ 影响因子：2.926； 五年影响因子：2.685 ）
ISSN：
年卷期：
页码：
收录情况： SCI
摘要： MicroRNA-8 and its target gene, u-shaped (ush), regulate body size in Drosophila. As the mouse homolog of the Drosophila miR-8, whether the miR-200 family has similar functions and how they perform their regulatory roles in body size control is unknown. In order to discover the biological function of the miR-200s in vivo, we generated mice lacking the miR-200b/200a/429 gene cluster using the Cre/loxp system. miR-200b/200a/429 null mutant mice were viable, fertile, and showed normal development.
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