您好，欢迎访问中国水产科学研究院 机构知识库！
中国水产科学研究院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Silymarin inhibits adipogenesis in the adipocytes in grass carp Ctenopharyngodon idellus in vitro and in vivo

文献类型： 外文期刊

作者： Xiao, Peizhen 1 ; Yang, Zhou 1 ; Sun, Jian 1 ; Tian, Jingjing 1 ; Chang, Zhiguang 1 ; Li, Xuexian 1 ; Zhang, Baotong 2 ;

作者机构： 1.Northwest A&F Univ, Coll Anim Sci & Technol, Yangling 712100, Peoples R China

2.Beijing Res Inst Nutr Resources, Open Lab Aquat Anim Nutr, Beijing 100069, Peoples R China

3.Soochow Univ, Sch Biol & Basic Med Sci, Key Lab Aquat Nutr Jiangsu Prov, Suzhou 215123, Peoples R China

4.Chinese Acad Fishery Sci, Pearl River Fisheries Res Inst, Key Lab Trop & Subtrop Fishery Resource Applicat, Minist Agr, Guangzhou 510380, Guangdong, Peoples R China

5.Chinese Acad Fishery Sci, Pearl River Fisheries Res Inst, Key Lab Trop & Subtrop Fishery Resource Applicat,

关键词： Silymarin;Adipogenesis;Grass carp;Adipocytes

期刊名称：FISH PHYSIOLOGY AND BIOCHEMISTRY （ 影响因子：2.794； 五年影响因子：2.876 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： In this study, two experiments were performed to explore the function of silymarin in adipogenesis in grass carp (Ctenopharyngodon idellus) using in vitro and in vivo models. In experiment 1, differentiated grass carp pre-adipocytes were treated with silymarin for 6 days. Treatment with 100 mu g mL(-1)silymarin (SM100 group) significantly reduced triglyceride accumulation at day 6. The adipogenic gene expression levels of PPAR gamma, C/EBP alpha, SREBP1c, FAS, SCD1, and LPL, and the protein expression level of PPAR gamma were significantly down-regulated in the SM100 group. Additionally, the SM100 group had significantly lower reactive oxygen species production and reduced glutathione contents compared with the control in vitro. In experiment 2, the juvenile grass carp (mean body weight= 27.4 +/- 0.17 g) were fed six isonitrogenous and isocaloric diets in a factorial design containing 0, 100, or 200 mg kg(-1) silymarin (SM0, SM100, SM200) associated with either 4 or 8% lipid levels (low lipid, LL, and high lipid, HL, respectively) for 82 days. The results demonstrated that dietary silymarin supplementation significantly reduced the elevated intraperitoneal fat index in grass carp fed with high-lipid diets, and the gene expression of adipogenesis (PPAR gamma, FAS) when supplemented with dietary silymarin was notably lower than when no silymarin was supplemented under the high-lipid diets. Thus, our data suggest that silymarin suppressed lipid accumulation in grass carp both in vitro and in vivo, and the effect might be due to an influence on the expression of adipogenesis factors and ROS production partly associated with effects on antioxidant capability.

  • 相关文献

[1]The protective effect of silymarin on the carbon tetrachloride (CCl4)-induced liver injury in common carp (Cyprinus carpio). Jia, Rui,Cao, Liping,Du, Jinliang,Xu, Pao,Yin, Guojun,Jeney, Galina. 2013

[2]Suppressive Effects of Quercetin-3-O-(6?-Feruloyl)-ss-D-Galactopyranoside on Adipogenesis in 3T3-L1 Preadipocytes Through Down-regulation of PPAR? and C/EBPa Expression. Yang, Lei,Zhang, Ya-Ou,Cai, Guo-Ping,Yang, Lei,Zhang, Ya-Ou,Cai, Guo-Ping,Li, Xiao-Fan,Gao, Lei. 2012

[3]The effect of emodin on cytotoxicity, apoptosis and antioxidant capacity in the hepatic cells of grass carp (Ctenopharyngodon idellus). Cui, Yan-ting,Liu, Bo,Xie, Jun,Xu, Pao,Habte-Tsion, H. -Michael,Zhang, Yuan-yuan,Cui, Yan-ting,Liu, Bo,Xie, Jun,Xu, Pao,Habte-Tsion, H. -Michael,Zhang, Yuan-yuan.

[4]Identification of a vasa homologue gene in grass carp and its expression pattern in tissues and during embryogenesis. Li, Chuang-Ju,Liu, Ling,Chen, Xi-Hua,Zhang, Tao,Gan, Fang,Cheng, Bao-Ling,Li, Chuang-Ju,Liu, Ling,Chen, Xi-Hua,Zhang, Tao,Gan, Fang.

[5]Genome-wide identification and characterization of conserved and novel microRNAs in grass carp (Ctenopharyngodon idella) by deep sequencing. Gong, Wangbao,Xie, Jun,Wang, Guangjun,Yu, Deguang,Huang, Yong,Sun, Xihong.

[6]Dietary supplementation of sodium butyrate may benefit growth performance and intestinal function in juvenile grass carp (Ctenopharyngodon idellus). Liu, Mengmei,Guo, Wei,Wu, Fan,Qu, Qicai,Tan, Qingsong,Gong, Wangbao.

[7]Molecular cloning and gene/protein expression of FAT/CD36 from grass carp (Ctenopharyngodon idella) and the regulation of its expression by dietary energy. Tian, Juan,Liu, Wei,Wu, Fan,Yu, Lijuan,Lu, Xing,Yang, Chang-Geng,Jiang, Ming,Wen, Hua,Tian, Juan,Jiang, Ming,Gao, Weihua.

[8]Effect of Ultrastructure on Changes of Textural Characteristics between Crisp Grass Carp (Ctenopharyngodon Idellus C.Et V) and Grass Carp (Ctenopharyngodon Idellus) Inducing Heating Treatment. Lin, Wan-Ling,Yang, Xian-Qing,Li, Lai-Hao,Hao, Shu-Xian,Wang, Jin-Xu,Huang, Hui,Wei, Ya,Wu, Yan-Yan.

[9]Transcriptome analysis of the grass carp (Ctenopharyngodon idella) using 454 pyrosequencing methodology for gene and marker discovery. Bai, J. J.. 2015

[10]RELATION BETWEEN PROTEIN CHARACTERISTICS AND TPA TEXTURE CHARACTERISTICS OF CRISP GRASS CARP (CTENOPHARYNGODON IDELLUS C. ET V) AND GRASS CARP (CTENOPHARYNGODON IDELLUS). Lin, Wan-Ling,Lin, Wan-Ling,Zeng, Qing-Xiao,Zhu, Zhi-Wei,Song, Guo-Sheng,Song, Guo-Sheng,Lin, Wan-Ling. 2012

[11]Occurrence of Bothriocephalus acheilognathi (Cestoda, Bothriocephallidea) in grass carp Ctenopharyngodon idella in the Changjiang River drainage. Wang Guitang,Wang Guitang,Xi Bingwen,Xie Jun. 2011

[12]The effect of hyperthermia on cell viability, oxidative damage, and heat shock protein expression in hepatic cells of grass carp (Ctenopharyngodon idellus). Cui, Yanting,Liu, Bo,Xie, Jun,Xu, Pao,Tsion, H. Michael H.,Zhang, Yuanyuan,Cui, Yanting,Liu, Bo,Xie, Jun,Xu, Pao,Zhang, Yuanyuan. 2013

[13]Respiratory response of grass carp Ctenopharyngodon idellus to dissolved oxygen changes at three acclimation temperatures. Zhao, Zhigang,Xu, Qiyou,Dong, Shuanglin. 2018

[14]Isolation, Identification, and Detection, of the Virulence Factor of Vibrio cholerae in Grass Carp. Teng, Tao,Liang, Liguo,Xie, Jun. 2015

[15]Determination of flavomycin residue in grass carp by high performance liquid chromatography. Tian Liang-liang,Huang Dong-mei,Shi Yong-fu,Han Feng,Zhou Peng. 2015

[16]Development of a reverse transcription loop-mediated isothermal amplification assay for rapid detection of grass carp reovirus. Zhang, Qing-Li,Yan, Yi,Shi, Cheng-Yin,Wang, Qin-Tao,Huang, Jie,Shen, Jin-Yu,Hao, Gui-Jie,Liu, Hong. 2013

[17]Effects of processing method and dietary lysine levels on growth performance, feed conversion ratio and body composition of grass carp, Ctenopharyngodon idella. Gan, Lian,Gan, Lian,Liu, Yong-Jian,Tian, Li-Xia,Liu, Fu-Jia,Yang, Hui-Jun,Chen, Yong-Jun,Liang, Gui-Yin,Yue, Yi-Rong. 2015

[18]Molecular cloning and expression of grass carp MyoD in yeast Pichia pastoris. Wang, Lixin,Bai, Junjie,Luo, Jianren,Chen, Hong,Ye, Xing,Jian, Qing,Lao, Haihua. 2007

[19]Oral delivery of Bacillus subtilis spores expressing cysteine protease of Clonorchis sinensis to grass carp (Ctenopharyngodon idellus): Induces immune responses and has no damage on liver and intestine function. Tang, Zeli,Sun, Hengchang,Chen, TingJin,Lin, Zhipeng,Jiang, Hongye,Zhou, Xinyi,Ren, Pengli,Yu, Jinyun,Li, Xuerong,Xu, Jin,Huang, Yan,Yu, Xinbing,Tang, Zeli,Sun, Hengchang,Chen, TingJin,Lin, Zhipeng,Jiang, Hongye,Zhou, Xinyi,Ren, Pengli,Yu, Jinyun,Li, Xuerong,Xu, Jin,Huang, Yan,Yu, Xinbing,Tang, Zeli,Sun, Hengchang,Chen, TingJin,Lin, Zhipeng,Jiang, Hongye,Zhou, Xinyi,Ren, Pengli,Yu, Jinyun,Li, Xuerong,Xu, Jin,Huang, Yan,Yu, Xinbing,Shi, Cunbin,Pan, Houjun,Chang, Ouqin.

[20]Effect of heat stress and recovery on viability, oxidative damage, and heat shock protein expression in hepatic cells of grass carp (Ctenopharyngodon idellus). Cui, Yanting,Liu, Bo,Xie, Jun,Xu, Pao,Habte-Tsion, H-Michael,Zhang, Yuanyuan,Cui, Yanting,Liu, Bo,Xie, Jun,Xu, Pao,Habte-Tsion, H-Michael,Zhang, Yuanyuan.

作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：中国水产科学研究院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台