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The toxic influence of paraquat on hippocampal neurogenesis in adult mice

文献类型： 外文期刊

作者： Li, Kaikai 1 ; Cheng, Xinran 1 ; Jiang, Jinhua 2 ; Wang, Jiutao 1 ; Xie, Jiongfang 1 ; Hu, Xinde 1 ; Huang, Yingxue 1 ; S 1 ;

作者机构： 1.Northwest A&F Univ, Coll Vet Med, Yangling 712100, Shaanxi, Peoples R China

2.Zhejiang Acad Agr Sci, Hangzhou 310021, Zhejiang, Peoples R China

3.China US Henan Hormel Canc Inst, Zhengzhou 450003, Henan, Peoples R China

关键词： Paraquat;Learning;Memory;Neurogenesis;Phosphorylation

期刊名称：FOOD AND CHEMICAL TOXICOLOGY （ 影响因子：6.023； 五年影响因子：5.844 ）

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收录情况： SCI

摘要： Paraquat, a fast-acting non-selective contact herbicide, is considered an etiological factor related to Parkinson's disease. This study investigated its effects on hippocampal neurogenesis and cognition in adult mice as well as possible mechanisms for the effects. We administered paraquat (1.25 mg/kg, intraperitoneal injection, i.p.) and an equal volume of normal saline for 3 weeks to adult male C57BL/6J mice. The results showed that hippocampus-dependent spatial learning and memory was significantly impaired in paraquat-treated mice. Moreover, paraquat administration inhibited the proliferation of neural progenitor cells, and impaired the survival and altered the fate decision of newly generated cells in the hippocampus. The expression levels of caspase-3 and glial fibrillary acidic protein were significantly higher in paraquat-treated mice than in control mice. Interestingly, paraquat reduced the phosphorylation of Akt, but did not affect the total amount of Ala. In conclusion, our findings suggest that paraquat negatively affected adult hippocampal neurogenesis and cognition function. (C) 2017 Elsevier Ltd. All rights reserved.

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