EFFECT OF A LYTIC BACTERIOPHAGE ON RABBITS EXPERIMENTALLY INFECTED WITH PATHOGENIC ESCHERICHIA COLI
文献类型： 外文期刊
作者： Zhao, J. 1 ; He, L. 3 ; Pan, L. 2 ; Liu, Y. 2 ; Yao, H. 1 ; Bao, G. 1 ;
作者机构： 1.Nanjing Agr Univ, Coll Vet Med, Nanjing 210014, Jiangsu, Peoples R China
2.Zhejiang Acad Agr Sci, Inst Anim Husb & Vet Sci, Hangzhou 310021, Zhejiang, Peoples R China
3.Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Surg, Boston, MA 02215 USA
关键词： atypical enteropathogenic Escherichia coil;bacteriophage;phage therapy;rabbit
期刊名称：WORLD RABBIT SCIENCE （ 影响因子：1.233； 五年影响因子：1.018 ）
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收录情况： SCI
摘要： Pathogenic Escherichia coli (E. coil) is severely threatening the rabbit industry in China, and the concern over antibiotic-resistant bacteria has given rise to an urgent need for antibiotic alternatives. In this study, a member (ZRP1) of the Myoviridae family was isolated from rabbit faeces using a strain of rabbit atypical enteropathogenic E. coil (ZR1) as host. The one-step growth curve indicated that the latent period was around 25 to 30 min and the burst size was 144 +/- 31 plaque-forming unit/cell. The rate of phage-resistant mutation was 7x10(-5)+/- 4x10(-5). When the bacteriophage input at the multiplicity of infection (MOI) was 0.1, 1 or 10, the growth of host E. coil in broth was inhibited for 5 h. A single intravenous injection of ZRP1 at MOI 0.1, 1 or 10 significantly prolonged the survival time of rabbits which simultaneously received a lethal dose of ZR1.
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