Short communication. Enhancement of the immune responses to vaccination against foot-and-mouth disease in mice by oral administration of Quillaja saponaria-A and extracts of Cochinchina momordica seed
文献类型： 外文期刊
作者： Xiao, C. W. 1 ; Rajput, Z. I. 2 ; Bao, G. 1 ; Hu, S. H. 2 ; Soomro, N. A. 3 ;
作者机构： 1.Zhejiang Acad Agr Sci, Inst Anim Husb & Vet Sci, Hangzhou 310021, Zhejiang, Peoples R China
2.Zhejiang Univ, Coll Anim Sci, Dept Vet Med, Hangzhou 310029, Zhejiang, Peoples R China
3.Directorate Anim Husb Sindh, Res & Dev Sect, Hyderabad 71000, Pakistan
关键词： adjuvant;ELISA;oral immunization;vaccine
期刊名称：SPANISH JOURNAL OF AGRICULTURAL RESEARCH （ 影响因子：1.238； 五年影响因子：1.731 ）
ISSN： 1695-971X
年卷期： 2013 年 11 卷 1 期
页码：
收录情况： SCI
摘要： This study was designed to evaluate the effects of oral administration of extracts from Cochinchina momordica seed (ECMS) or Quillaja saponaria-A (Quil-A) on the immune responses in mice immunized with foot and mouth disease virus (FMDV)-serotype O vaccine. Forty-two imprinting control region (ICR) mice were randomly divided into seven groups of 6 animals in each group, and a dose of 400 mu g of Quil-A or ECMS was orally administered for 1, 2 or 3 days. After that, the animals were subcutaneously immunized twice with FMD vaccine at 3-week intervals and blood samples were collected 2-weeks after boosting for measurement of FMDV-specific IgG and its subclasses. Spleens were collected for lymphocytes proliferation assay. Results indicated that serum FMDV-specific IgG and the IgG subclass responses were significantly enhanced in mice orally administered ECMS or Quil-A when compared with the control group (p < 0.05). Lymphocytes proliferation response to FMD vaccine was significantly enhanced by ECMS compared with the control (p < 0.05). This study illustrates that ECMS induced immunomodulatory effects and performed better than Quil-A.
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