New Azaphilones from the Marine-Derived Fungus Penicillium sclerotiorum E23Y-1A with Their Anti-Inflammatory and Antitumor Activities
文献类型： 外文期刊
作者： Zeng, Yanbo 1 ; Wang, Zhi 1 ; Chang, Wenjun 1 ; Zhao, Weibo 1 ; Wang, Hao 1 ; Chen, Huiqin 1 ; Dai, Haofu 1 ; Lv, Fang 3 ;
作者机构： 1.Chinese Acad Trop Agr Sci, Hainan Prov Key Lab Funct Components Res & Utiliza, Inst Trop Biosci & Biotechnol, Haikou 571101, Peoples R China
2.Hainan Inst Trop Agr Resources, Key Lab Biol & Genet Resources Trop Crops Hainan P, Haikou 571101, Peoples R China
3.Beijing Inst Technol, Sch Life Sci, Beijing Key Lab Separat & Anal Biomed & Pharmaceut, Beijing 100081, Peoples R China
4.Zhanjiang Expt Stn Chinese Acad Trop Agr Sci, Zhanjiang 524013, Peoples R China
关键词： marine-derived fungus; Penicillium sclerotiorum; azaphilones; structure elucidation; anti-inflammatory activity; antitumor activity
期刊名称：MARINE DRUGS （ 影响因子：5.4； 五年影响因子：5.5 ）
ISSN：
年卷期： 2023 年 21 卷 2 期
页码：
收录情况： SCI
摘要： Nine new azaphilones, including penicilazaphilones I-N (1, 2 and 6-9), epi-geumsanol D (3) and penidioxolanes C (4) and D (5) were isolated from the culture of the marine-derived fungus Penicillium sclerotiorum E23Y-1A. The structures of the isolates were deduced from extensive spectroscopic data (1D and 2D NMR), high-resolution electrospray ionization mass spectrometry (HRESIMS), and electronic circular dichroism (ECD) calculations. All the azaphilones from P. sclerotiorum E23Y-1A were tested for their anti-inflammatory and antitumor activities. Penicilazaphilone N (9) showed moderate anti-inflammatory activity with an IC50 value of 22.63 +/- 2.95 mu M, whereas penidioxolane C (4) exhibited moderate inhibition against human myeloid leukemia cells (K562), human liver cancer cells (BEL-7402), human gastric cancer cells (SGC-7901), human non-small cell lung cancer cells (A549), and human hela cervical cancer cells, with IC50 values of 23.94 +/- 0.11, 60.66 +/- 0.13, 46.17 +/- 0.17, 60.16 +/- 0.26, and 59.30 +/- 0.60 mu M, respectively.
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