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The pharmacokinetic characteristics of sulfadiazine in channel catfish (Ictalurus punctatus) following oral and intravenous administrations

文献类型： 外文期刊

作者： Xu, Ning 1 ; Fu, Yu 3 ; Zhang, Xiaomei 4 ; Liu, Yongtao 1 ; Yang, Yibin 1 ; Zhou, Shun 1 ; Dong, Jing 1 ; Yang, Qiuhong 1 ;

作者机构： 1.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, 8 Wuda Pk Rd 1, Wuhan 430223, Hubei, Peoples R China

2.Hu Bei Prov Engn & Technol Res Ctr Aquat Prod Qua, Wuhan, Peoples R China

3.Hunan Univ Arts & Sci, Changde, Peoples R China

4.Hunan Appl Technol Univ, Changde, Peoples R China

5.Minist Agr, Key Lab Control Qual & Safety Aquat Prod, Beijing, Peoples R China

关键词： bioavailability; channel catfish; pharmacokinetics; sulfadiazine

期刊名称：JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS （ 影响因子：1.786； 五年影响因子：1.7 ）

ISSN： 0140-7783

年卷期：

页码：

收录情况： SCI

摘要： This study aimed to determine the bioavailability and pharmacokinetic parameters of sulfadiazine (SDZ) in channel catfish (Ictalurus punctatus) following oral gavage and intravenous injection. The healthy channel catfish were orally and intravenously administrated with SDZ solution at doses of 50 and 5 mg/kg, respectively. Plasma samples were determined by ultra-performance liquid chromatography with an ultraviolet detector. The results demonstrated that the concentration-time profile of SDZ after oral dosing was best described by a one-compartmental open model with first-order absorption. The absorption half-life (t(1/2K alpha)), the elimination half-life (t(1/2Ke)), and the area under concentration-time profile (AUC(0-infinity)) were estimated to be 0.87 h, 29.04 h, and 1311.72 mg.h/L, respectively. After intravenous administration, the concentration-time curve of SDZ conformed to a two-compartmental open model without absorption. The distribution half-life (t(1/2 alpha)), the elimination half-life (t(1/2 beta)), the apparent distribution volume (V-ss), the total clearance (CL), and AUC(0-infinity) were calculated to be 0.19 h, 14.24 h, 0.36 L/kg, 0.018 L/h/kg, and 277.12 mg.h/L, respectively. Finally, the bioavailability was estimated to be 47.33%. This study will provide some useful information for the modification of the dosage form of SDZ in aquaculture, and is partly beneficial for appropriate use of SDZ in the future.

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