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Oridonin-induced apoptosis in SW620 human colorectal adenocarcinoma cells

文献类型： 外文期刊

作者： Ji, Zhe 1 ; Tang, Qingjiu 1 ; Zhang, Jinsong 1 ; Yang, Yan 1 ; Liu, Yanfang 1 ; Pan, Yingjie 3 ;

作者机构： 1.Shanghai Acad Agr Sci, Inst Edible Fungi, Natl Engn Res Ctr Edible Fungi,Shanghai Key Lab A, Key Lab Appl Mycol Resources & Utilizat,Minist Ag, Shanghai 201106, Peoples R China

2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai 200031, Peoples R China

3.Shanghai Fisheries Un

关键词： apoptosis;caspase-3;oridonin

期刊名称：ONCOLOGY LETTERS （ 影响因子：2.967； 五年影响因子：2.575 ）

ISSN： 1792-1074

年卷期： 2011 年 2 卷 6 期

页码：

收录情况： SCI

摘要： Oridonin, a diterpenoid isolated from Rabdosia rubescens (Hemsl.) Hara, inhibited the growth of human tumor cell lines SW620 (colon), MCF-7 (breast) and K562 (bone marrow), and induced significant levels of apoptosis in SW620. Morphological changes indicative of cell apoptosis were observed after the cells were exposed to oridonin for 24 h. Growth inhibition was associated with G1 phase arrest, and with time- and dose-dependent increases in caspase-3 activity. We therefore conclude that oridonin inhibits the proliferation of SW620 cells by induction of apoptosis via the activation of caspase-3. Our data suggest that oridonin may have significant potential as an anti-colorectal adenocarcinoma agent.

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