Immunomodulation of Bone Marrow Macrophages by GLIS, a Proteoglycan Fraction from Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidium (W.Curt.: Fr.) P. Karst.
文献类型: 外文期刊
作者: Ji, Zhe 1 ; Tang, Qingjiu 1 ; Zhang, Jinsong 1 ; Yang, Yan 1 ; Liu, Yanfang 1 ; Pan, Yingjie 3 ;
作者机构: 1.Shanghai Acad Agr Sci, Key Lab Appl Mycol Resources & Utilizat, Natl Engn Res Ctr Edible Fungi, Inst Edible Fungi,Minist Agr,Shanghai Key Lab Agr, Shanghai 201106, Peoples R China
2.Chinese Acad Sci, Key Lab Nutr & Metab, Inst Nutr Sci, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China
3.Shangh
关键词: medicinal mushrooms;cytokines;Ganoderma lucidum;immunoactivation;bone marrow macrophages
期刊名称:INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS ( 影响因子:1.921; 五年影响因子:1.879 )
ISSN: 1521-9437
年卷期: 2011 年 13 卷 5 期
页码:
收录情况: SCI
摘要: The immunomodulatory effect of GUS (Lingzhi or Reishi medicinal mushroom Ganoderma lucidum immunomodulating substance) on macrophages has been investigated as part of ongoing research into the anticancer properties of this mushroom. Proliferation of bone marrow macrophages (BMMs) was enhanced by GLIS in a dose-dependent manner. Microscopic examination revealed that numerous GLIS-treated BMMs were enlarged and formed pseudopodia. Exposure of BMMs to GLIS resulted in significant increases in NO production, induction of cellular respiratory burst activity, and increased levels of IL-1 beta, IL-6, IL-12p35, IL-12p40, IL-18, and TNF-alpha gene expression and levels of TNF-alpha, IL-1 beta, and IL-12 secretion. Our data indicate that GUS activates the immune system by modulating cytokine production.
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