您好，欢迎访问上海市农业科学院 机构知识库！
上海市农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

GLIS, a bioactive proteoglycan fraction from Ganoderma lucidum, displays anti-tumour activity by increasing both humoral and cellular immune response

文献类型： 外文期刊

作者： Zhang, Jingsong 1 ; Tang, Qingjiu 1 ; Zhou, Changyan 1 ; Jia, Wei 1 ; Da Silva, Luis 3 ; Nguyen, Long Duc 1 ; Reutter, 1 ;

作者机构： 1.Charite Univ Med Berlin, Inst Mol Biol & Biochem, CBF, D-14195 Berlin, Germany

2.Shanghai Acad Agr Sci, Edible Fungi Inst, Shanghai, Peoples R China

3.Charite Univ Med Berlin, Inst Physiol, CBF, D-14195 Berlin, Germany

关键词： Ganoderma lucidum (G. lucidum);Traditional Chinese medicine (TCM);B lymphocytes;Macrophages;Anti-tumour;Proteoglycan

期刊名称：LIFE SCIENCES （ 影响因子：5.037； 五年影响因子：4.689 ）

ISSN： 0024-3205

年卷期： 2010 年 87 卷 19-22 期

页码：

收录情况： SCI

摘要： Aims: Ganoderma lucidum, a traditional Chinese medicine, is well known as a modulator of functions of the immune system as well as an anti-tumour agent. However, its active compounds and their molecular mechanisms of action are not well established. GLIS, a proteoglycan isolated from the fruiting body of G. lucidum, stimulates directly the activation of B lymphocytes. In this work, the immunoactivation capacities of GLIS as well as its anti-tumour effect were investigated in vitro and in vivo. Main methods: Tumour-bearing mice were prepared by inoculation of mouse sarcoma S180 cells into BALB/c mice. Lymphocytes and bone marrow-derived macrophages were isolated from spleen and tibia/femurs, respectively. After stimulation with GLIS different immune responses of these cells were analysed. Antitumour effect of GLIS was determined. Key findings: After treatment with GLIS, spleen-derived B lymphocytes from tumour-bearing mice became activated, proliferated and produced large amounts of immunoglobulins. Bone marrow-derived macrophages from tumour-bearing mice also became activated after exposure to GLIS, and they produced important immunomodulatory substances, such as IL-1 beta, TNF-alpha and reactive nitrogen intermediates, like NO. GLIS markedly increased phagocytosis of macrophages, and very importantly, it markedly raised the macrophage-mediated tumour cytotoxicity. Treatment of mice with GLIS caused an inhibition of mouse sarcoma S180 tumour growth by 60% in vivo. Significance: These results indicate that GLIS exhibits a capacity to increase remarkably both humoral and cellular immune activities of tumour-bearing mice and inhibits tumour growth significantly. The anti-tumour effect of GLIS results from its capacity to increase the host's immune activity. (C) 2010 Elsevier Inc. All rights reserved.

  • 相关文献

[1]Preparation of a novel sulfated glycopeptide complex and inhibiting L1210 cell lines property in vitro. Ye, LiBin,Zhang, JingSong,Zhou, Shuai,Ye, LiBin,Wang, Sheng,Wu, Di,Pan, YingJie.

[2]Activation of B lymphocytes by GLIS, a bioactive proteoglycan from Ganoderma lucidum. Zhang, JS,Tang, QJ,Zimmerman-Kordmann, M,Reutter, W,Fan, H. 2002

[3]Biochemical characterization of a proteoglycan complex from an edible mushroom Ganoderma lucidum fruiting bodies and its immunoregulatory activity. Ye, LiBin,Zheng, Xiaolin,Wang, Xiangyang,Li, Jianrong,Zhang, Jingsong,Tang, Qingqiu,Yang, Yan,Liu, YanFang,Pan, YingJie.

[4]Production of IgM by B Cells After Stimulation with GLIS from Ganoderma lucidum Mushroom. QINGJIU TANG,JINGSONG ZHANG,WERNER REUTTER,HUA FAN,Shanghai Academy of Agricultural Sciences(SAAS); Shanghai Academy of Agricultural Sciences(SAAS);. 2005

[5]Caveolin-1-mediated endocytic pathway is involved in classical swine fever virus Shimen infection of porcine alveolar macrophages. Ning, Pengbo,Zhang, Xianghan,Ning, Pengbo,Guo, Kangkang,Gao, Lifang,Zhou, Yulu,Hu, Congxia,Gong, Cunmei,Lin, Zhi.

[6]Purification and Characterization of a Novel Small-Molecule Polysaccharide from the Maitake Medicinal Mushroom Grifola frondosa (Higher Basidiomycetes). Zhou, Changyan,Wu, Aizhong,Zhou, Changyan,Wu, Aizhong,Qiao, Yanru,Tang, Qingjiu,Jia, Wei,Liu, Yanfang,Qiao, Yanru. 2013

作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：上海市农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台