文献类型： 外文期刊

作者： Yu, Hai ² ; Zhang, Peng-Chao ¹ ; Zhou, Yan-Jun ² ; Li, Guo-Xin ² ; Pan, Jie ¹ ; Yan, Li-Ping ² ; Shi, Xiao-Xiao ¹ ; Liu, ¹ ;

作者机构： 1.Shanghai Acad Agr Sci, Inst Anim Sci & Vet Med, Shanghai Key Lab Agr Genet & Breeding, Shanghai 201106, Peoples R China

2.Chinese Acad Agr Sci, Shanghai Vet Res Inst, Div Swine Infect Dis, Shanghai 200241, Peoples R China

关键词： Swine influenza;Avian-like H1N1 influenza virus;Novel ressortant H1N2 influenza virus;Phylogenetic analysis

期刊名称：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS （ 影响因子：3.575； 五年影响因子：3.381 ）

ISSN： 0006-291X

年卷期： 2009 年 386 卷 2 期

页码：

收录情况： SCI

摘要： As pigs are susceptible to both human and avian influenza viruses, they have been proposed to be intermediate hosts or mixing vessels for the generation of pandemic influenza viruses through reassortment or adaptation to the mammalian host. In this study, we reported avian-like H1N1 and novel ressortant H1N2 influenza viruses from pigs in China. Homology and phylogenetic analyses showed that the H1N1 virus (A/swine/Zhejiang/1/07) was closely to avian-like H1N1 viruses and seemed to be derived from the European swine H1N1 viruses, which was for the first time reported in China; and the two H1N2 viruses (A/swine/Shanghai/1/07 and A/swine/Guangxi/13/06) were novel ressortant H1N2 influenza viruses containing genes from the classical swine (HA, NP, M and NS), human (NA and PB1) and avian (PB2 and PA) lineages, which indicted that the reassortment among human, avian, and swine influenza viruses had taken place in pigs in China and resulted in the generation of new viruses. The isolation of avian-like H1N1 influenza virus originated from the European swine H1N1 viruses, especially the emergence of two novel ressortant H1N2 influenza viruses provides further evidence that pigs serve as intermediate hosts or "mixing vessels", and swine influenza virus surveillance in China should be given a high priority. (C) 2009 Published by Elsevier Inc.