文献类型： 外文期刊

作者： Yu, Hai ¹ ; Zhou, Yan-Jun ¹ ; Li, Guo-Xin ¹ ; Zhang, Gui-Hong ² ; Liu, Hui-Li ³ ; Yan, Li-Ping ¹ ; Liao, Ming ² ; Tong, G ¹ ;

作者机构： 1.Chinese Acad Agr Sci, Shanghai Vet Res Inst, Div Swine Infect Dis, Shanghai 200241, Peoples R China

2.So China Agr Univ, Coll Vet Med, Guangzhou 510642, Guangdong, Peoples R China

3.Shanghai Acad Agr Sci, Inst Anim Sci & Vet Med, Shanghai 201106, Peoples R China

关键词： Swine influenza;Human-like H1N1 influenza virus;Phylogenetic analysis;Molecular characterization;Seroprevalence

期刊名称：VIRUS RESEARCH （ 影响因子：3.303； 五年影响因子：3.445 ）

ISSN： 0168-1702

年卷期： 2009 年 140 卷 1-2 期

页码：

收录情况： SCI

摘要： Classical swine and avian-like H1N1 influenza viruses were reported widely in swine population worldwide, but human-like H1N1 swine viruses were reported occasionally. In 2006, a human-like H1N1 swine virus (A/swine/Guangdong/96/06) was isolated from pigs in Guangdong province, which was reported in China for the first time. To get further evidence for infection of pigs with human-like H1N1 influenza viruses, we analyzed eight gene segments of three human-like swine H1N1 viruses (A/swine/Guangdong/96/06, A/swine/Tianjin/01/04 and A/swine/Henan/01/06) isolated in China. All the eight genes of the three viruses are highly homologous to recent (about 2000) and early (1980s) human H1N1 influenza viruses, respectively. Phylogenetic analyses revealed that A/Swine/Guangdong/96/06 was directly derived from about 2000 human H1N1 influenza viruses, while A/swine/Tianjin/01/04 and A/swine/Henan/01/06 seemed to be descendants of human HI NI viruses circulating in 1980s. Seroprevalence of our isolate (A/swine/Guangdong/96/06) confirmed the presence of human-like H1N1 virus in pigs in China. Existence of these influenza viruses, especially older viruses (A/swine/Tianjin/01/04 and A/swine/Henan/01/06), indicates that human-like H1N1 influenza viruses may remain invariant for long periods in pigs and provides the evidence that pigs serve as reservoirs of older influenza viruses for human pandemics. (C) 2008 Elsevier B.V. All rights reserved.