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Newly Characterized Porcine Epidemic Diarrhea Virus GII Subtype Strain

文献类型： 外文期刊

作者： Yu, Jiarong 1 ; Chen, Pengfei 2 ; Liu, Ruilin 1 ; Lao, Mengqin 1 ; Zhu, Junrui 1 ; Zhou, Shuting 3 ; Jiang, Jijie 3 ; Huang, Shijing 1 ; Tong, Wu 1 ; Jiang, Yifeng 1 ; Gao, Fei 1 ; Yu, Lingxue 1 ; Yu, Hai 1 ; Liu, Changlong 1 ; Yang, Zhibiao 3 ; Tong, Guangzhi 1 ; Zhou, Yanjun 1 ;

作者机构： 1.Chinese Acad Agr Sci, Shanghai Vet Res Inst, Shanghai 200241, Peoples R China

2.Shanghai Acad Agr Sci, Inst Anim Sci & Vet Med, Shanghai, Peoples R China

3.Shanghai Jiao Tong Univ, Sch Agr & Biol, Shanghai Key Lab Vet Biotechnol, Shanghai 200240, Peoples R China

4.Yangzhou Univ, Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou 225009, Peoples R China

期刊名称：TRANSBOUNDARY AND EMERGING DISEASES （ 影响因子：4.3； 五年影响因子：4.3 ）

ISSN： 1865-1674

年卷期： 2023 年 2023 卷

页码：

收录情况： SCI

摘要： Diarrhea outbreaks in piglets on pig farms are commonly attributed to porcine epidemic diarrhea virus (PEDV) infection. This research analyzed the S gene prevalence variation and recombination patterns in PEDV GII strains. Throughout the previous two years, 172 clinical samples of piglet diarrhea have been collected, from which 24 PEDV isolates have been isolated. Analysis of the evolutionary relationships among all 24 S genes revealed that 21 were most closely related to strains within the GII-a subgroup. The 2 isolates grouped into one clade with the GII-b subgroup. According to the mutation analysis of the amino acids (aa) that encode the S protein, 43 of the common aa in strains of the GII subtype were found to have undergone a change in polarity or charge, and 36 of these aa had a mutation frequency of more than 90%. Three different aa mutation sites were identified as exclusive to GII-a subtype strains. The genomes of three PEDV isolates were sequenced, and the resulting range in genome length was 28,035-28,041 nt. The results of recombination analysis showed that the SD1 isolate is a novel strain recombinant from the foreign S-INDEL strain and a domestic GII subtype strain. Based on the findings, the PEDV GII-a strain has been the most circulating strain in several parts of China during the previous two years. Our study reveals for the first time the unique change of aa mutations in the S protein of the GII-a subtype strain and the new characteristics of the recombination of foreign strains and domestic GII subtype strains, indicating that it is crucial to monitor the epidemic dynamics of PEDV promptly to prevent and control the occurrence of PED effectively.

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