Evaluation of the changes of immune cells during lipopolysaccharide-induced mastitis in rats
文献类型： 外文期刊
作者： Miao, Jin-Feng 1 ; Zhu, Yu-Min 2 ; Gu, Bei-Bei 1 ; Wang, Xiao-Bin 3 ; Zou, Si-Xiang 1 ; Deng, Yue-E 1 ;
作者机构： 1.Nanjing Agr Univ, Coll Vet Med, Nanjing 210095, Peoples R China
2.Shanghai Acad Agr Sci, Inst Anim Sci & Vet Med, Shanghai 201106, Peoples R China
3.Southeast Univ, Expt Anim Ctr, Nanjing 210009, Peoples R China
关键词： lipopolysaccharide;immune cells;cytokines;rat mastitis
期刊名称：CYTOKINE （ 影响因子：3.861； 五年影响因子：4.257 ）
ISSN： 1043-4666
年卷期： 2007 年 40 卷 2 期
页码：
收录情况： SCI
摘要： The aim of this study was to evaluate in rats, changes in peripheral blood immune cells and mammary tissue after an intramammary infusion of lipopolysaccharide (LPS). The results of the study showed that infusion of LPS induced a rapid migration of neutrophils (PMNs) from the blood to mammary alveoli, increased the activity of myeloperoxidase (MPO) and the concentration of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), and interleukin-6 (IL-6) in mammary tissues, decreased the activity of myeloperoxidase in serum and reduced the CD4+/CD8+ ratio. This is the first report of changes in peripheral blood immune cells and mammary tissue in rat mastitis. (C) 2007 Elsevier Ltd. All rights reserved.
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