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Characterization of the porcine p65 subunit of NF-kappa B and its association with virus antibody levels

文献类型： 外文期刊

作者： Li, Hegang 2 ; Ma, Guojian 2 ; Gui, Duan 2 ; Zhao, Shuanping 2 ; Wang, Pan 2 ; He, Kongwang; Wang, Xuemin; Ruan, Ji 1 ;

作者机构： 1.Huazhong Agr Univ, Coll Vet Med, Lab Vet Pharmacol & Toxicol, Wuhan 430070, Hubei, Peoples R China

2.Chinese Acad Agr Sci, Inst Anim Sci, Minist Agr China, Key Lab Farm Anim Genet Resources & Utilizat, Beijing 100193, Peoples R China

3.Chinese Acad Agr Sci

关键词： NF-kappaB;p65;Pig;Genomic structure;Transrepression;Association analysis

期刊名称：MOLECULAR IMMUNOLOGY （ 影响因子：4.407； 五年影响因子：4.227 ）

ISSN： 0161-5890

年卷期： 2011 年 48 卷 6-7 期

页码：

收录情况： SCI

摘要： NF-kappa B p65 subunit plays important roles in controlling both innate and adaptive immunity. Here we report the characterization of porcine NF-kappa B p65 subunit (pp65). pp65 shows high similarity to other mammalian counterparts. pp65 mRNA expression was mainly observed in lung, spleen, liver and small intestine. Furthermore, overexpression of pp65 activates NF-kappa B in porcine endothelial cell line PIEC, porcine alveolar macrophages cell line 3D4/21 and porcine primary fetal fibroblasts. A COOH-terminal truncation derivative of pp65 (pp65RHD) has been identified as a specific transdominant inhibitor of NF kappa B. Association study was performed on the selected SNP and indel. The results revealed that the SNP BgII was significantly associated (P<0.05) with pig reproduction and respiratory syndrome virus antibody level (PRRSV-AB) (0 day and 17 days), the classical swine fever virus (CSFV) antibody blocking rates (CSFV-AB) (0 day and 17 days) and pseudorabies virus antibody level (PRV-AB) (0 day and 32 days). (C) 2011 Elsevier Ltd. All rights reserved.

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