文献类型: 外文期刊
作者: Tian, Juan 1 ; Wang, Kaidi 1 ; Wang, Xuan 1 ; Wen, Hua 2 ; Zhou, Huihui 1 ; Liu, Chengdong 1 ; Mai, Kangsen 1 ; He, Gen 1 ;
作者机构: 1.Ocean Univ China, Key Lab Aquaculture Nutr, Minist Agr, Qingdao 266003, Peoples R China
2.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Key Lab Freshwater Biodivers Conservat, Minist Agr, Wuhan 430223, Hubei, Peoples R China
3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peo
关键词: Soybean saponin;Zebrafish;TOR pathway;IGF;Metabolic enzymes
期刊名称:GENERAL AND COMPARATIVE ENDOCRINOLOGY ( 影响因子:2.822; 五年影响因子:2.772 )
ISSN: 0016-6480
年卷期: 2018 年 257 卷
页码:
收录情况: SCI
摘要: Soybean saponin (SA) is known as a major anti-nutritional factor that causes metabolic disturbances and growth reduction in fish. However, the mechanisms underlying these effects were far from fully understood. In particular, the influences of SA on nutrient sensing and downstream metabolic pathways remain largely unexplored. Using zebrafish as an animal model, this study was conducted to examine the phenotypic and molecular responses after dietary SA treatment for 2 weeks. SA at both 5 and 10 g/kg diet levels significantly reduced growth performance and feed efficiency, and damaged the morphology of the intestinal mucosa. SA stimulated AMP-activated protein kinase but reduced target of rapamycin (TOR) activities in both feeding trial and cellular studies. Furthermore, SA increased the mRNA expressions of growth axis genes including growth hormone, insulin-like growth factor 1, growth hormone receptor A, and growth hormone receptor B, but decreased insulin-like growth factor-binding protein 2 at both mRNA and protein levels. SA also increased the expressions of key metabolic enzymes involved in glutamine synthetase, glutamate dehydrogenase and lipolysis, hormone-sensitive lipase and lipoprotein lipase. Our results demonstrated that SA modulated nutrient sensing pathways and metabolism, thus provide new aspects on the explanation of the physiological effects of SA. (C) 2017 Elsevier Inc. All rights reserved.
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