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Pharmacokinetics of sulfamonomethoxine in tongue sole (Cynoglossus semilaevis) after intravenous and oral administration

文献类型： 外文期刊

作者： Chang, Zhi-Qiang 1 ; Li, Zhao-Xin 1 ; Li, Jing-Bao 1 ; Wang, Ying-Zi 1 ; Li, Jian 1 ;

作者机构： 1.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Qingdao 266071, Peoples R China

关键词： Sulfamonomethoxine;Pharmacokinetics;Tongue sole

期刊名称：FISH PHYSIOLOGY AND BIOCHEMISTRY （ 影响因子：2.794； 五年影响因子：2.876 ）

ISSN： 0920-1742

年卷期： 2014 年 40 卷 4 期

页码：

收录情况： SCI

摘要： The pharmacokinetic profiles of sulfamonomethoxine (SMM) were investigated in flatfish tongue soles in the present study. After a single injection of SMM (40 mg/kg BW) to caudal vein of tongue sole at 20 A degrees C, plasma drug concentration versus time data were best fitted to a three-compartment model, characterized with 0.2, 5.7, and 80.4 h for the half-life (t (1/2)) of fast distribution, slow distribution, and elimination, respectively. The apparent volume of distribution was 0.1 L/kg, and the body clearance was 0.03 L/h/kg. After oral administration of SMM (200 mg/kg BW) to tongue soles at 20 A degrees C, plasma drug concentrations were best fitted to a two-compartment model, of which the mean half-life of absorption (t (1/2ka)) and elimination (t (1/2 beta) ) were 1.7 and 95.7 h, respectively. The maximal absorption concentration (C (max)) was estimated as 58 mg/L at 2.5 h, and the mean systemic bioavailability (F) was 39.5 % in tongue soles after oral administration.

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