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Impact of Bisphenol A exposure on maternal gut microbial homeostasis, placental function, and fetal development during pregnancy

文献类型： 外文期刊

作者： Zha, Xia 1 ; Elsabagh, Mabrouk 5 ; Zheng, Yi 1 ; Zhang, Bei 1 ; Wang, Hongrong 1 ; Bai, Yila 4 ; Zhao, Jingwen 1 ; Wang, Mengzhi 1 ; Zhang, Hao 1 ;

作者机构： 1.Yangzhou Univ, Coll Anim Sci & Technol, Lab Metab Manipulat Herbivorous Anim Nutr, Yangzhou 225009, Peoples R China

2.Yangzhou Univ, Joint Int Res Lab Agr & Agriprod Safety, Minist Educ China, Yangzhou 225009, Peoples R China

3.Xinjiang Acad Agr & Reclamat Sci, State Key Lab Sheep Genet Improvement & Hlth Prod, Shihezi 832000, Peoples R China

4.Xilin Gol League Anim Husb Xilinhot, Xilinhot 026000, Peoples R China

5.Nigde Omer Halisdemir Univ, Fac Agr Sci & Technol, Dept Anim Prod & Technol, TR-51240 Nigde, Turkiye

6.Kafrelsheikh Univ, Fac Vet Med, Dept Nutr & Clin Nutr, Kafrelsheikh 33516, Egypt

关键词： Gut microbiota; Bisphenol A; Pregnancy; Placenta; Fetal development; Gut-placental axis

期刊名称：REPRODUCTIVE TOXICOLOGY （ 影响因子：3.3； 五年影响因子：3.1 ）

ISSN： 0890-6238

年卷期： 2024 年 129 卷

页码：

收录情况： SCI

摘要： Pregnancy is extremely vulnerable to external environmental influences. Bisphenol A, an endocrine-disrupting chemical, poses a significant environmental hazard to individuals of all ages and stages, particularly during pregnancy. The placenta is a temporary organ facilitating the connection between the mother and fetus. While it can detoxify certain exogenous substances, it is also vulnerable to the impacts of endocrine disruptors. Likewise, the intestinal flora is highly sensitive to exogenous stresses and environmental pollutants. The regulation of gut microbiota plays a crucial role in ensuring the health of both the mother and the fetus. The gut-placental axis connects the gut, gut microbes, placenta, and fetus. Exploring possible effects on placental function and fetal development involves analyzing changes in gut microbiota composition. Given that bisphenol A may cross the intestine and affect intestinal function, gut microorganisms, and their metabolites, as well as its potential impact on the placenta, resulting in impaired placental function and fetal development, this study aims to establish a link between bisphenol A exposure, intestinal microorganisms, placental function, and fetal development. This paper seeks to analyze the effects of maternal exposure to bisphenol A during pregnancy on the balance of the maternal gut microbiota, placental function, and fetal development, considering the key role of the gut-placental axis. Additionally, this paper proposes potential directions for future research emphasizing the importance of mitigating the adverse outcomes of bisphenol A exposure during pregnancy in both human and animal studies.

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