Establishment and Characterization of Stable Zein/Glycosylated Lactoferrin Nanoparticles to Enhance the Storage Stability and in vitro Bioaccessibility of 7,8-Dihydroxyflavone
文献类型： 外文期刊
作者： Chen, Yufeng 1 ; Gao, Xiaojing 1 ; Liu, Shucheng 2 ; Cai, Qiuxing 3 ; Wu, Lijun 1 ; Sun, Yi 1 ; Xia, Guobin 4 ; Wang, Yueqi 3 ;
作者机构： 1.Zhejiang Univ Technol, Coll Food Sci & Technol, Hangzhou, Peoples R China
2.Guangdong Ocean Univ, Coll Food Sci & Technol, Guangdong Prov Key Lab Aqut Prod Proc & Safety, Zhanjiang, Peoples R China
3.Beibu Gulf Univ, Coll Food Engn, Qinzhou, Peoples R China
4.Texas Childrens Hosp, Dept Pediat Sect Neonatol, Houston, TX 77030 USA
5.Chinese Acad Fishery Sci, South China Sea Fisheries Res Inst, Key Lab Aqut Prod Proc, Minist Agr & Rural Affairs Peoples Republ China, Guangzhou, Peoples R China
关键词： zein; glycosylated lactoferrin; nanoparticles; bioaccessibility; 7; 8-dihydroxyflavone
期刊名称：FRONTIERS IN NUTRITION （ 影响因子：6.59； 五年影响因子：6.873 ）
ISSN： 2296-861X
年卷期： 2022 年 8 卷
页码：
收录情况： SCI
摘要： In this work, the lactoferrin (LF) was glycosylated by dextran (molecular weight 10, 40, and 70 kDa, LF 10K, LF 40K, and LF 70K) via Maillard reaction as a stabilizer to establish zein/glycosylated LF nanoparticles and encapsulate 7,8-dihydroxyflavone (7,8-DHF). Three zein/glycosylated LF nanoparticles (79.27-87.24 nm) with low turbidity (<0.220) and polydispersity index (PDI) (<0.230) were successfully established by hydrophobic interactions and hydrogen bonding. Compared with zein/LF nanoparticles, zein/glycosylated LF nanoparticles further increased stability to ionic strength (0-500 mM NaCl) at low pH conditions. Zein/glycosylated LF nanoparticles had nanoscale spherical shape and glycosylated LF changed surface morphology of zein nanoparticles. Besides, encapsulated 7,8-DHF exhibited an amorphous state inside zein/glycosylated LF nanoparticles. Most importantly, zein/glycosylated LF nanoparticles had good water redispersibility, high encapsulation efficiency (above 98.50%), favorable storage stability, and bioaccessibility for 7,8-DHF, particularly LF 40K. Collectively, the above research provides a theoretical reference for the application of zein-based delivery systems.
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