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In vitro synergistic effects of fisetin and norfloxacin against aquatic isolates of Serratia marcescens

文献类型： 外文期刊

作者： Dong, Jing 1 ; Ruan, Jing 3 ; Xu, Ning 1 ; Yang, Yibin 1 ; Ai, Xiaohui 1 ;

作者机构： 1.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Wudayuan Rd 8, Wuhan 430223, Peoples R China

2.Hubei Freshwater Aquaculture Collaborat Innovat C, Shizishan St 1, Wuhan 430070, Peoples R China

3.Chinese Acad Sci, Inst Hydrobiol, Donghu South Rd 7, Wuhan 430072, Peoples R China

关键词： Serratia marcescens;resistance;fisetin;synergism

期刊名称：FEMS MICROBIOLOGY LETTERS （ 影响因子：2.742； 五年影响因子：2.856 ）

ISSN： 0378-1097

年卷期： 2016 年 363 卷 1 期

页码：

收录情况： SCI

摘要： Serratia marcescens is a common pathogenic bacterium that can cause infections in both humans and animals. It can cause a range of diseases, from slight wound infections to life-threatening bacteraemia and pneumonia. The emergence of antimicrobial resistance has limited the treatment of the diseases caused by the bacterium to a great extent. Consequently, there is an urgent need to develop novel antimicrobial strategies against this pathogen. Synergistic strategy is a new approach to treat the infections caused by drug-resistant bacteria. In this paper, we isolated and identified the first multi-resistant pathogenic Serratia marcescens strain from diseased soft-shelled turtles (Pelodiscus sinensis) in China. We then performed a checkerboard assay; the results showed that out of 10 tested natural products fisetin had synergistic effects against S. marcescens when combined with norfloxacin. The time-kill curve assay further confirmed the results of the checkerboard assay. We found that this novel synergistic effect could significantly reduce the dosage of norfloxacin against S. marcescens.

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