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Functional Characterization of the Almstn2 Gene and Its Association with Growth Traits in the Yellowfin Seabream Acanthopagrus latus (Hottuyn, 1782)

文献类型： 外文期刊

作者： Guo, Jianyi 1 ; Guo, Huayang 2 ; Chen, Chuanghua 1 ; Yu, Fangzhao 1 ; Liu, Baosuo 2 ; Zhang, Nan 2 ; Xian, Lin 2 ; Luo, Zhiping 1 ; Liu, Wen 1 ; Zhu, Kecheng 2 ; Zhang, Dianchang 3 ;

作者机构： 1.Modern Agr Dev Ctr Zhuhai City, Zhuhai 519000, Peoples R China

2.Chinese Acad Fishery Sci, South China Sea Fisheries Res Inst, Key Lab South China Sea Fishery Resources Exploita, Minist Agr & Rural Affairs, 231 Xingang Rd West, Guangzhou 510300, Peoples R China

3.Guangdong Prov Engineer Technol Res Ctr Marine Bio, Guangzhou 510300, Peoples R China

4.Sanya Trop Fisheries Res Inst, Sanya 572018, Peoples R China

关键词： Acanthopagrus latus; mstn2; gene expression; SNP

期刊名称：GENES （ 影响因子：3.5； 五年影响因子：3.9 ）

ISSN：

年卷期： 2023 年 14 卷 12 期

页码：

收录情况： SCI

摘要： Myostatin (mstn), also known as GDF8, is a growth and differentiation factor of the transforming growth factor-beta (TGF-beta) superfamily and plays a key inhibitory effect in the regulation of skeletal muscle development and growth in vertebrates. In the present study, to comprehend the role of the mstn2 gene of the yellowfin seabream Acanthopagrus latus (Almstn2b), the genomic sequence of Almstn2b is 2359 bp, which encodes 360 amino acids and is composed of three exons and two introns, was obtained. Two typical regions, a TGF-beta propeptide and TGF-beta domain, constitute Almstn2b. The topology indicated that Almstn2 was grouped together with other Perciformes, such as the gilthead seabream Sparus aurata. Moreover, Almstn2b was mainly expressed in the brain, fins, and spleen. Furthermore, five SNPs, one in the exons and four in the introns, were identified in the Almstn2b gene. The allele and genotype frequencies of SNP-Almstn2b +1885 A/G were significantly related to the total weight, interorbital distance, stem length, tail length, caudal length, caudal height, body length, and total length (p < 0.05). The allele and genotype frequencies of SNP-Almstn2b +1888 A/G were significantly related to the weight, interorbital distance, long head behind the eyes, body height, tail length, caudal length, and body length. Additionally, the relationship between the SNP-Almstn2b +1915 A/G locus and weight and long head behind the eyes was significant (p < 0.05). Furthermore, the other two SNPs were not significantly associated with any traits. Thus, the SNPs identified in this study could be utilized as candidate SNPs for breeding and marker-assisted selection in A. latus.

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