Matrine Ameliorates DSS-Induced Colitis by Suppressing Inflammation, Modulating Oxidative Stress and Remodeling the Gut Microbiota
文献类型： 外文期刊
作者： Mao, Ningning 1 ; Yu, Yaming 1 ; He, Jin 1 ; Yang, Yang 1 ; Liu, Zhenguang 1 ; Lu, Yu 3 ; Wang, Deyun 1 ;
作者机构： 1.Nanjing Agr Univ, Coll Vet Med, Inst Tradit Chinese Vet Med, Nanjing 210095, Peoples R China
2.Nanjing Agr Univ, Coll Vet Med, MOE Joint Int Res Lab Anim Hlth & Food Safety, Nanjing 210095, Peoples R China
3.Jiangsu Acad Agr Sci, Inst Vet Immunol & Engn, Nanjing 210014, Peoples R China
关键词： DSS; matrine; ulcerative colitis; Treg/Th17; gut microbiota
期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：4.9； 五年影响因子：5.6 ）
ISSN： 1661-6596
年卷期： 2024 年 25 卷 12 期
页码：
收录情况： SCI
摘要： Matrine (MT) possesses anti-inflammatory, anti-allergic and antioxidative properties. However, the impact and underlying mechanisms of matrine on colitis are unclear. The purpose of this research was to examine the protective impact and regulatory mechanism of matrine on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in mice. MT alleviated DSS-induced UC by inhibiting weight loss, relieving colon shortening and reducing the disease activity index (DAI). Moreover, DSS-induced intestinal injury and the number of goblet cells were reversed by MT, as were alterations in the expression of zonula occludens-1 (ZO-1) and occludin in colon. Simultaneously, matrine not only effectively restored DSS-induced oxidative stress in colonic tissues but also reduced the production of inflammatory cytokines. Furthermore, MT could treat colitis mice by regulating the regulatory T cell (Treg)/T helper 17 (Th17) cell imbalance. We observed further evidence that MT alleviated the decrease in intestinal flora diversity, reduced the proportion of Firmicutes and Bacteroidetes, decreased the proportion of Proteobacteria and increased the relative abundance of Lactobacillus and Akkermansia in colitis mice. In conclusion, these results suggest that MT may mitigate DSS-induced colitis by enhancing the colon barrier integrity, reducing the Treg/Th17 cell imbalance, inhibiting intestinal inflammation, modulating oxidative stress and regulating the gut microbiota. These findings provide strong evidence for the development and application of MT as a dietary treatment for UC.
- 相关文献
作者其他论文 更多>>
-
Cyclic-di-AMP hydrolase GdpP is critical for stress response of Lactiplantibacillus plantarum WCFS1
作者：Yu, Zhaoqing;Dai, Zhuqing;He, Weiwei;Yang, Wenying;Li, Dajing;Chou, Shan-Ho;He, Jin;Chou, Shan-Ho;He, Jin;Pang, Xinyi
关键词：Lactiplantibacillus plantarum; Second messenger; Stress response; Biofilm; Cell envelope
-
Enhanced Immunogenicity of Chicken H9N2 Influenza Inactivated Vaccine Through a Novel Dual-Targeting Fusion Protein Strategy
作者：Xu, Hai;Feng, Yaming;Xu, Hai;Deng, Bihua;Zhu, Yalu;Qi, Qiurong;Feng, Yaming;Deng, Bihua;Lu, Yu;Wu, Erzhong
关键词：dual targeting; avian influenza; dendritic cell; envelope virus
-
Nano-adjuvant based on lipo-imiquimod self-assembly for enhanced foot-and-mouth disease virus vaccine immune responses via intradermal immunization
作者：Yin, Wenzhu;Ma, Fang;Deng, Bihua;Zhao, Yanhong;Zuo, Xiaoxin;Wang, Haiyan;Lu, Yu;Xu, Zeyu;Zhao, Yanhong;Lu, Yu;Yin, Wenzhu;Deng, Bihua
关键词：Imiquimod; Lipidation; Self-assembly; Nano-adjuvant; Intradermal immunity; Foot-and-mouth vaccine
-
YiMu-QingGong san alleviates lipopolysaccharide-induced endometritis in mice via inhibiting inflammation and oxidative stress through regulating macrophage polarization
作者：Yu, Yaming;Mao, Ningning;Yu, Lin;Lin, Fangzhu;Shi, Xiaofeng;Lu, Xuanqi;Yang, Yang;Wang, Deyun;Yu, Yaming;Mao, Ningning;Yu, Lin;Lin, Fangzhu;Shi, Xiaofeng;Lu, Xuanqi;Yang, Yang;Wang, Deyun;Lu, Yu
关键词：Macrophage polarization; Inflammation; Endometritis; NF-kappa B; Fibrosis; Uterine barrier
-
Enhanced Immunogenicity of Foot-and-Mouth Disease Virus-like Particles Using a Water-in-Oil-in-Water Adjuvant
作者：Zhou, Yujie;Qian, Yingjuan;Zhou, Yujie;Yin, Wenzhu;Zhao, Yanyan;Lu, Yu;Deng, Bihua;Zhou, Yujie;Zhao, Yanyan;Lu, Yu;Qian, Yingjuan;Yin, Wenzhu;Lu, Yu;Deng, Bihua;Teng, Zhidong;Lu, Yu
关键词：foot-and-mouth disease; virus-like particle; W/O/W double emulsion; adjuvant
-
Construction of vitamin E-based oil-in-water nano-emulsion adjuvant enhances immunogenicity of inactivated pseudorabies virus vaccine
作者：Yin, Wenzhu;Chang, Chen;Zhu, Yalu;Ma, Fang;Wang, Haiyan;Lu, Yu;Tang, Bo;Deng, Bihua;Yin, Wenzhu;Zhu, Yalu;Lu, Yu;Deng, Bihua
关键词：Oil-in-water emulsion; Nano-adjuvant; Vitamin E; Pseudorabies virus; Immune response
-
A Scalable and Robust Chloroplast Genotyping Solution: Development and Application of SNP and InDel Markers in the Maize Chloroplast Genome
作者：Wang, Rui;Yang, Yang;Tian, Hongli;Yi, Hongmei;Xu, Liwen;Ge, Jianrong;Zhao, Yikun;Wang, Lu;Wang, Fengge;Lv, Yuanda;Zhou, Shiliang
关键词：chloroplast; SNP; InDel; high throughput; genotyping; maize
