Clostridium butyricum and carbohydrate active enzymes contribute to the reduced fat deposition in pigs
文献类型： 外文期刊
作者： Ma, Lingyan 1 ; Tao, Shiyu 2 ; Song, Tongxing 2 ; Lyu, Wentao 1 ; Li, Ying 3 ; Wang, Wen 1 ; Shen, Qicheng 1 ; Ni, Yan 4 ; Zhu, Jiang 1 ; Zhao, Jiangchao 5 ; Yang, Hua 1 ; Xiao, Yingping 1 ;
作者机构： 1.Zhejiang Acad Agr Sci, State Key Lab Managing Biot & Chem Threats Qual &, Inst Agroprod Safety & Nutr, Hangzhou, Peoples R China
2.Huazhong Agr Univ, Coll Anim Sci & Technol, Dept Anim Nutr & Feed Sci, Wuhan, Peoples R China
3.Foshan Univ, Coll Life Sci & Engn, Guangdong Prov Key Lab Anim Mol Design & Precise B, Foshan, Peoples R China
4.Zhejiang Univ, Sch Med, Childrens Hosp, Natl Clin Res Ctr Child Hlth, Hangzhou, Peoples R China
5.Univ Arkansas, Dept Anim Sci, Div Agr, Fayetteville, AR 72701 USA
关键词： CAZymes; Clostridium butyricum; fatness; gut microbiota; Jinhua pigs; metagenomics
期刊名称：IMETA （ 影响因子：33.2； 五年影响因子：33.2 ）
ISSN： 2770-5986
年卷期： 2024 年 3 卷 1 期
页码：
收录情况： SCI
摘要： Pig gastrointestinal tracts harbor a heterogeneous and dynamic ecosystem populated with trillions of microbes, enhancing the ability of the host to harvest energy from dietary carbohydrates and contributing to host adipogenesis and fatness. However, the microbial community structure and related mechanisms responsible for the differences between the fatty phenotypes and the lean phenotypes of the pigs remained to be comprehensively elucidated. Herein, we first found significant differences in microbial composition and potential functional capacity among different gut locations in Jinhua pigs with distinct fatness phenotypes. Second, we identified that Jinhua pigs with lower fatness exhibited higher levels of short-chain fatty acids in the colon, highlighting their enhanced carbohydrate fermentation capacity. Third, we explored the differences in expressed carbohydrate-active enzyme (CAZyme) in pigs, indicating their involvement in modulating fat storage. Notably, Clostridium butyricum might be a representative bacterial species from Jinhua pigs with lower fatness, and a significantly higher percentage of its genome was dedicated to CAZyme glycoside hydrolase family 13 (GH13). Finally, a subsequent mouse intervention study substantiated the beneficial effects of C. butyricum isolated from experimental pigs, suggesting that it may possess characteristics that promote the utilization of carbohydrates and hinder fat accumulation. Remarkably, when Jinhua pigs were administered C. butyricum, similar alterations in the gut microbiome and host fatness traits were observed, further supporting the potential role of C. butyricum in modulating fatness. Taken together, our findings reveal previously overlooked links between C. butyricum and CAZyme function, providing insight into the basic mechanisms that connect gut microbiome functions to host fatness.
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