Metabolic responses of golden trout (Oncorhynchus mykiss aguabonita) after acute exposure to waterborne copper
文献类型： 外文期刊
作者： Chen, Yan 1 ; Cheng, Bo 2 ; Liu, Yang 3 ; Bai, Yucen 4 ; Yang, Xiaofei 1 ; Xu, Shaogang 1 ;
作者机构： 1.Beijing Acad Agr & Forestry Sci, Fisheries Sci Inst, Beijing Key Lab Fishery Biotechnol, Beijing 100097, Peoples R China
2.Chinese Acad Fishery Sci, Key Lab Aquat Prod Proc, Minist Agr & Rural Affairs, Beijing, Peoples R China
3.Qinghai Univ, Coll Ecoenvironm Engn, Xining 810016, Peoples R China
4.China Rural Technol Dev Ctr, 54 Sanlihe Rd, Beijing 100045, Peoples R China
关键词： Copper; Metabolomics; Acute exposure
期刊名称：AQUATIC TOXICOLOGY （ 影响因子：5.202； 五年影响因子：5.758 ）
ISSN： 0166-445X
年卷期： 2022 年 249 卷
页码：
收录情况： SCI
摘要： Despite the broad knowledge of copper-induced stress and toxicity, data on the physiological responses to acute copper exposure and the correlation of those activities to a generalized stress response are still limited. The present study aimed to assess the physiological responses of golden trout to overcome copper stress at concentrations of 60 mu g/L and 120 mu g/L after 96 h, respectively. The activities of glucose-6-phosphate dehydrogenase (G6PD) phosphoenolpyruvate carboxykinase (PEPCK) and NADPH/NADP(+) ratio were significantly increased, and metabolites including glucose 6-phosphate, fructose 1-phosphate and fatty acids significantly accumulated in fish liver, indicating that gluconeogenesis, the pentose-phosphate pathway, as well as alteration of the membrane fatty acid composition were activated to serve as a defense mechanism against 60 mu g/L of copper after 96 h. After exposure to 120 mu g/L of copper for 96 h, the NAD(+) and ATP contents, the activities of enzymes in the glycolytic pathway (phosphofructokinase, PFK and pyruvate kinase, PK) and mitochondrial respiratory chain complex I decreased significantly in fish liver. In addition, carbohydrates and MDA accumulated in golden trout after 120 mu g/L copper treatment. These results indicated that 120 mu g/L of copper exposure may induce a metabolic stress in golden trout after 96 h. The multi-marker approach allows us to reach a greater understanding of the effects of copper on physiological responses of golden trout.
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