Identification and yield of metabolites of chlorinated paraffins incubated with chicken liver microsomes: Assessment of their potential to convert into metabolites
文献类型： 外文期刊
作者： Huang, Xiaomei 1 ; Xu, Kaihang 1 ; Lyu, Lina 4 ; Ding, Chenhong 1 ; Zhao, Yarong 1 ; Wang, Xu 1 ;
作者机构： 1.Guangdong Acad Agr Sci, Inst Qual Stand & Monitoring Technol Agroprod, Guangzhou 510640, Peoples R China
2.Guangdong Prov Key Lab Qual & Safety Risk Assessme, Guangzhou 510640, Peoples R China
3.Minist Agr & Rural Affairs, Lab Qual & Safety Risk Assessment Agroprod Guangzh, Guangzhou 510640, Peoples R China
4.Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Peoples R China
关键词： Short-chain chlorinated paraffin; Medium-chain chlorinated paraffin; Long-chain chlorinated paraffin; Metabolic elimination; Hydroxylated metabolite
期刊名称：JOURNAL OF HAZARDOUS MATERIALS （ 影响因子：13.6； 五年影响因子：12.7 ）
ISSN： 0304-3894
年卷期： 2023 年 455 卷
页码：
收录情况： SCI
摘要： Chlorinated paraffins (CPs) are emerging environmental pollutants. Although metabolism has been shown to affect the differential accumulation of short-chain (SCCPs), medium-chain (MCCPs) and long-chain (LCCPs) CPs in birds, CP metabolites have rarely been reported and the extent to which they are formed is still unclear. In this study, single and mixed CP standards were incubated with chicken liver microsomes in vitro to study the gen-eration of CP metabolites. Putative aldehyde/ketone and carboxylic acid metabolites identified by mass spec-troscopy data were shown to be false positive results. Phase I metabolism of CPs first formed monohydroxylated ([M-Cl+OH]) and then dihydroxylated ([M-2Cl+2OH]) products. The yields of monohydroxylated metabolites of CPs decreased with increasing carbon chain length and chlorine content at the initial stage of reaction. Notably, the yield of monohydroxylated metabolites of SCCPs with 51.5% Cl content reached 21%, and that of 1,2,5,6,9,10-hexachlorodecane (C10H16Cl6) was as high as 71%. Thus, monohydroxy metabolites of CPs in birds should not be ignored, especially those of SCCPs. This study provides important data that could support im-provements to the ecological/health risk assessment of CPs.
- 相关文献
作者其他论文 更多>>
-
Heavy Metal-Induced Assembly of DNA Network Biosensor from Double-Loop Hairpin Probes for Ultrasensitive Detection of UO2+2 ° in Water and Soil Samples
作者：Wang, Xu;Guo, Junhui;Chen, Junhua;Lv, Yiwen;Chen, Manjia;Tong, Hui;Chen, Junhua;Liu, Chengshuai
关键词：
-
The pivotal role of secondary nutrients and micronutrients in regulating fruit quality and root exudates metabolism profile of citrus
作者：Tang, Yanni;Wang, Pengwei;Zhou, Yingjie;Zhan, Ting;Zhang, Siming;Hu, Chengxiao;Tan, Qiling;Zhao, Xiaohu;Tang, Yanni;Lou, Wei;Yan, Xiang;Li, Shiqian;Zhao, Xiaohu;Wang, Xu;Liu, Hanliang
关键词：Citrus; Secondary nutrients and micronutrients; Fruit quality; Root exudates; Metabolomics
-
Microplastics in aquafeeds: Occurrence, sources, effects and considerations for aquatic food production
作者：Su, Zeliang;Wei, Liangfu;Zhi, Linyong;Wang, Jun;Wang, Xu;Wei, Liangfu;Huang, Xiaomei
关键词：Aquafeeds; Aquaculture; Analytical methods; Microplastics; Sources
-
Intelligent monitoring of the available lead (Pb) and cadmium (Cd) in soil samples based on half adder and half subtractor molecular logic gates
作者：Chen, Junhua;Liu, Chengshuai;Chen, Junhua;Lv, Yiwen;Chen, Manjia;Tong, Hui;Wang, Xu
关键词：Molecular logic gate; Intelligent sensing; DNA recognition; Heavy metal; Available Pb; Available Cd
-
pOsHAK1:OsSUT1 Promotes Sugar Transport and Enhances Drought Tolerance in Rice
作者：Chen, Guang;Lian, Wenli;Geng, Anjing;Wang, Yihan;Liu, Minghao;Zhang, Yue;Wang, Xu;Chen, Guang;Lian, Wenli;Geng, Anjing;Wang, Yihan;Liu, Minghao;Zhang, Yue;Wang, Xu;Chen, Guang;Lian, Wenli;Geng, Anjing;Wang, Yihan;Liu, Minghao;Zhang, Yue;Wang, Xu
关键词：rice; drought tolerance; sugar transport; inducible promoter
-
Polyethylene is degraded by the deep-sea Acinetobacter venetianus bacterium
作者：Lyu, Lina;Tian, Xinpeng;Zhang, Si;Zhang, Si;Fang, Kejing;Huang, Xiaomei
关键词：Deep sea; Bacteria; Acinetobacter; Degradation; Plastic
-
AflaILVB/G/I and AflaILVD are involved in mycelial production, aflatoxin biosynthesis, and fungal virulence in Aspergillus flavus
作者：Zhao, Yarong;Huang, Chulan;Zeng, Rui;Chen, Peirong;Xu, Kaihang;Huang, Xiaomei;Wang, Xu;Zhao, Yarong;Huang, Chulan;Zeng, Rui;Chen, Peirong;Xu, Kaihang;Huang, Xiaomei;Wang, Xu;Zhao, Yarong;Huang, Chulan;Zeng, Rui;Chen, Peirong;Xu, Kaihang;Huang, Xiaomei;Wang, Xu
关键词：Aspergillus flavus; aflatoxin biosynthesis; branched-chain amino acids; AflaILVB/G/I; AflaILVD; fungal secondary metabolites
