Toxic Effects of Povidone-Iodine on Macrobrachium rosenbergii: Concentration-Dependent Responses in Oxidative Stress, Immunosuppression, and Recovery Potential
文献类型： 外文期刊
作者： Jiao, Tianhui 1 ; Wang, Yakun 1 ; Wei, Jie 1 ; Xu, Sikai 1 ; Zhou, Qiaoyan 1 ; Mu, Xidong 1 ; Yu, Lingyun 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Pearl River Fisheries Res Inst, Minist Agr & Rural Affairs, Key Lab Trop & Subtrop Fishery Resources Applicat, Guangzhou 510380, Peoples R China
2.Shanghai Ocean Univ, Coll Fisheries & Life Sci, Shanghai 201306, Peoples R China
关键词：
disinfectant; povidone-iodine; aquaculture industry;
期刊名称：ANIMALS （ 影响因子：2.7； 五年影响因子：3.2 ）
ISSN： 2076-2615
年卷期： 2025 年 15 卷 15 期
页码：
收录情况： SCI
摘要： Povidone-iodine (PVP-I), a widely used aquaculture disinfectant, remains poorly understood in terms of sublethal toxicity and damage reversibility. This study employed Macrobrachium rosenbergii as the model organism to evaluate the acute toxicity and sublethal effects of PVP-I through a 4-day exposure experiment followed by a 7-day depuration period. Acute toxicity tests enabled the determination of 24-96 h median lethal concentrations (LC50), with the 96 h LC50 being 5.67 mg/L and the safe concentration (SC) being 1.37 mg/L. Based on this, three sublethal concentrations (1.14, 1.89, and 2.84 mg/L) were tested over a 4-day exposure followed by a 7-day depuration period. Investigated endpoints included gill ultrastructure, apoptosis, and antioxidant and immune-related gene expression. Subacute exposure at 1.89 and 2.84 mg/L induced mitochondrial vacuolization, upregulated apoptosis-related genes (Cyt-c, Caspase-3, Bok), and downregulated antioxidant gene expression (SOD, CAT, GSH-Px). The high-concentration group also showed sustained Toll-like receptor (Toll) gene overexpression and acid phosphatase (ACP) gene suppression. After depuration, antioxidant gene expression normalized; however, apoptotic markers in gill tissue remained impaired. Overall, high PVP-I concentrations cause irreversible gill damage via mitochondrial-mediated apoptosis, whereas lower concentrations (<= 1.14 mg/L) allow for greater recovery. These results offer crucial toxicodynamic insights for safer PVP-I use and risk assessment in M. rosenbergii aquaculture.
- 相关文献
作者其他论文 更多>>
-
Identification of two effective sex-specific DNA markers in silver arowana ( Osteoglossum bicirrhosum)
作者：Liu, Yi;Liu, Chao;Yang, Yexin;Wang, Yuanyuan;Mu, Xidong;Sun, Jinhui;Yang, Yexin
关键词：Osteoglossidae; Silver arowana; Sex-specific markers; ZW sex-determination
-
Reference genome provide insights into sex determination of silver aworana (Osteoglossum bicirrhosum)
作者：Liu, Yi;Yang, Yexin;Wang, Yuanyuan;Liu, Chao;Ouyang, Guochang;Xu, Meng;Mu, Xidong;Bian, Chao;Shi, Qiong;Ma, Ka Yan;Ouyang, Guochang;Sun, Jinhui;Shao, Changwei;Chen, Jiehu;Yang, Yexin
关键词：Silver arowana; Whole-genome sequencing and assembly; Chromosome interaction; Transcriptome; Female-specific region;
foxl2 -
Effects of different feeding strategies for the frozen Antarctic krill meal on growth, muscle nutrition, digestive enzyme activity, immunity, molting, and gut microbiota structure of Cherax quadricarinatus
作者：Mai, Zhuang;Liu, Fubai;Yang, Tianyan;Mai, Zhuang;Wei, Jie;Wang, Yakun;Liu, Fubai;Li, Huarong;Su, Qiyao;Hong, Kunhao;Zhou, Qiaoyan;Jiao, Tianhui;Yu, Lingyun;Zeng, Zhongqiang;Li, Huarong;Su, Qiyao;Hong, Kunhao;Jiao, Tianhui
关键词：Antarctic krill meal; Cherax quadracarinatus; growth performance; fatty acid; immunity-related gene
-
Role of myostatin promoter mutations in growth and molting regulation of Macrobrachium rosenbergii
作者：Su, Qiyao;Wei, Jie;Wang, Yakun;Liufu, Bai;Li, Huarong;Mai, Zhuang;Hong, Kunhao;Zhou, Qiaoyan;Jiao, Tianhui;Mu, Xidong;Yu, Lingyun;Su, Qiyao;Li, Huarong;Hong, Kunhao;Jiao, Tianhui;Liufu, Bai;Mai, Zhuang
关键词：
Macrobrachium rosenbergii ;myostatin ; RNAi; molt; growth -
Development of 68 SSR markers for Hemibagrus guttatus, a protected indigenous catfish in China
作者：Yang, Yexin;Liu, Yi;Song, Jiahuan;Liu, Chao;Mu, Xidong;Yang, Yexin;Zhu, Shandian;Xiong, Bingyuan;Wu, Yuli
关键词：SSR markers; Hemibagrus guttatus; Genetic diversity; Whole-genome resequencing
-
Comparative Transcriptomic Analysis of Male and Female Gonads in the Zig-Zag Eel (Mastacembelus armatus)
作者：Cui, Fangyu;Wang, Yuanyuan;Yang, Yexin;Song, Jiahuan;Liu, Chao;Mu, Xidong;Liu, Yi;Cui, Fangyu;Liang, Haiyan;Jiang, Zhiyong;Wu, Yuli
关键词：
Mastacembelus armatus ; transcriptome; sex differentiation; gonadal development; differentially expressed genes -
Chromosome-level genome assembly reveals adaptive evolution of the invasive Amazon sailfin catfish (Pterygoplichthys pardalis)
作者：Lv, Yunyun;Li, Yanping;Zou, Yuanchao;Shi, Qiong;Fang, Miao;Liu, Yi;Wang, Yuanyuan;Yang, Yexin;Mu, Xidong;Shi, Qiong
关键词：
