Residue, biotransformation, risk assessment and withdrawal time of enrofloxacin in red swamp crayfish (Procambarus clarkii)
文献类型： 外文期刊
作者： Liu, Yongtao 1 ; Ai, Xiaohui 1 ; Sun, Ruyu 1 ; Yang, Yibin 1 ; Zhou, Shun 1 ; Dong, Jing 1 ; Yang, Qiuhong 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Wuhan 430223, Peoples R China
2.Hubei Prov Engn & Technol Res Ctr Aquat Prod Qual, Wuhan 430223, Peoples R China
3.Minist Agr, Key Lab Control Qual & Safety Aquat Prod, Beijing 100141, Peoples R China
4.Shanghai Ocean Univ, Coll Fisheries & Life Sci, Shanghai 201306, Peoples R China
关键词： Crayfish; Enrofloxacin; Biotransformation; Risk assessment; Withdrawal time
期刊名称：CHEMOSPHERE （ 影响因子：8.943； 五年影响因子：8.52 ）
ISSN： 0045-6535
年卷期： 2022 年 307 卷
页码：
收录情况： SCI
摘要： Crayfish is a very popular aquatic food in many countries, and enrofloxacin (ENR) and ciprofloxacin (CIP) was the most frequently detected in aquatic products. However, limited information is available on the residue characterization, biotransformation rate and withdrawal period (WT) of ENR and CIP in crayfish and health risk via consumption of ENR and CIP remained crayfish. Herein, a comprehensive investigation was conducted to study residue depletion, biotransformation, ingestion risk, and WT of ENR and its predominate metabolite CIP in crayfish following different routes with repeated doses. The results showed that the elimination half-life (T-1/2) of target compounds in crayfish were all in order of hepatopancreas > muscle > gill, and the order of T-1/2 in different crayfish tissues were intramuscular (IM) route > oral (PO) treatment > immersion (IMMR) administration. The biotransformation rates from ENR to CIP varied from 0.75% to 3.45% in crayfish tissues following different exposure mutes. The high dietary risk (RQ > 1) consuming muscle and hepatopancreas of ENR and CIP remained crayfish occurred at early after different administrations. WT is the key to control the drug residue risk, and the longest WT of marker residue of ENR in crayfish was calculated to be 51 d (1275 degrees C-day).
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