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Effects of molecular weight on intestinal anti-inflammatory activities of beta-D-glucan from Ganoderma lucidum

文献类型： 外文期刊

作者： Liu, Yanfang 1 ; Tang, Qingjiu 1 ; Feng, Jie 1 ; Liu, Jing 1 ; Tang, Chuanhong 1 ; Yan, Mengqiu 1 ; Zhou, Shuai 1 ; Liu, Liping 1 ; Zhou, Jing 1 ; Zhang, Jingsong 1 ;

作者机构： 1.Shanghai Acad Agr Sci, Inst Edible Fungi, Minist Agr, Shanghai, Peoples R China

2.Minist Agr, Key Lab Edible Fungi Resources & Utilizat South, Shanghai, Peoples R China

3.Natl Engn Res Ctr Edible Fungi, Shanghai, Peoples R China

4.Shanghai Baixin Biotech Co Ltd, Shanghai, Peoples R China

关键词： Ganoderma lucidum; beta-(1 -> 3,1 -> 6)-D-glucan; molecular weight; inflamed Caco-2 cells; DSS-induced colitis; inflammatory cytokines

期刊名称：FRONTIERS IN NUTRITION （ 影响因子：6.59； 五年影响因子：6.873 ）

ISSN： 2296-861X

年卷期： 2022 年 9 卷

页码：

收录情况： SCI

摘要： To investigate the influence of molecular weight (M-w) on the anti-inflammatory activity of beta-D-glucan from Ganoderma lucidum, ultrasonic irradiation was applied to treat the beta-D-glucan (GLP, 2.42 x 10(6) g/mol) solution to obtain two degraded fractions with molecular weight of 6.53 x 10(5) g/mol (GLPC) and 3.49 x 10(4) g/mol (GLPN). Structural analysis proved that the degraded fractions possessed similar repeated units with the original beta-D-glucan. The in vitro anti-inflammatory activity studies showed that all fractions could significantly inhibit LPS-induced expression of cytokines including TNF-alpha, IL-8, MIF and MCP-1 in Caco-2 cells at certain concentrations. Moreover, GLPC and GLPN exhibited better anti-inflammatory activity than GLPC. The intestinal anti-inflammatory activity evaluated by dextran sulfate sodium (DSS)-induced colitis mice model showed that intragastric administration of GLPN (lower M-w fraction) could significantly recover inflamed tissues of mice. Compared with GLP and GLPC, GLPN exhibited stronger ability to inhibit the secretion of pro-inflammatory cytokines (TNF-alpha, IL-1 beta, and IL-6). The results revealed that M-w of beta-D-glucan influenced its anti-inflammatory activity and decreasing of M-w would improve the activity, which provided evidence for the potential use of beta-B-glucan from G. lucidum as anti-colitis ingredients.

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