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Defining context-dependent m6A RNA methylomes in Arabidopsis

文献类型： 外文期刊

作者： Zhang, Bin 1 ; Zhang, Songyao 2 ; Wu, Yujin 1 ; Li, Yan 2 ; Kong, Lingyao 2 ; Wu, Ranran 2 ; Zhao, Ming 1 ; Liu, Wei 2 ; Yu, Hao 1 ;

作者机构： 1.Natl Univ Singapore, Temasek Life Sci Lab, Singapore 117604, Singapore

2.Natl Univ Singapore, Fac Sci, Dept Biol Sci, Singapore 117543, Singapore

3.Qingdao Univ, Coll Life Sci, Qingdao 266071, Peoples R China

4.Jiangsu Acad Agr Sci, Inst Ind Crops, Nanjing 210014, Peoples R China

5.Shandong Acad Agr Sci, Inst Crop Germplasm Resources, Jinan 250100, Peoples R China

期刊名称：DEVELOPMENTAL CELL （ 影响因子：8.7； 五年影响因子：11.4 ）

ISSN： 1534-5807

年卷期： 2024 年 59 卷 20 期

页码：

收录情况： SCI

摘要： N 6-Methyladenosine (m6A) prevalently occurs on cellular RNA across almost all kingdoms of life. It governs RNA fate and is essential for development and stress responses. However, the dynamic, context-dependent m6A methylomes across tissues and in response to various stimuli remain largely unknown in multicellular organisms. Here, we generate a comprehensive census that identifies m6A methylomes in 100 samples during development or following exposure to various external conditions in Arabidopsis thaliana. We demonstrate that m6A is a suitable biomarker to reflect the developmental lineage, and that various stimuli rapidly affect m6A methylomes that constitute the regulatory network required for an effective response to the stimuli. Integrative analyses of the census and its correlation with m6A regulators identify multiple layers of regulation on highly context-dependent m6A modification in response to diverse developmental and environmental stimuli, providing insights into m6A modification dynamics in the myriad contexts of multicellular organisms.

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