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Maternal thyroid hormones affect zebrafish embryo development

文献类型： 外文期刊

作者： Rodrigues, Maira da Silva 1 ; de Souza, Beatriz Marques 1 ; Rosa, Ivana Felipe 1 ; Doretto, Lucas Benites 2 ; Nobrega, Rafael Henrique 1 ;

作者机构： 1.Sao Paulo State Univ UNESP, Inst Biosci, Dept Struct & Funct Biol, Reprod & Mol Biol Grp, BR-18618689 Botucatu, Brazil

2.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, State Key Lab Mariculture Biobreeding & Sustainabl, Qingdao 266071, Peoples R China

关键词： Thyroid hormones; Maternal THs transfer; Somatotropic axis; Zebrafish

期刊名称：MOLECULAR AND CELLULAR ENDOCRINOLOGY （ 影响因子：3.6； 五年影响因子：3.8 ）

ISSN： 0303-7207

年卷期： 2025 年 607 卷

页码：

收录情况： SCI

摘要： Thyroid hormones (THs), including thyroxine (T4) and triiodothyronine (T3), regulate vertebrate development, influencing critical processes during embryogenesis and larval stages. However, their maternal transfer and developmental roles in fish remain poorly understood. This study investigates maternal THs' impact on zebrafish development, focusing on the somatotropic axis, a key regulator of growth and metabolism. Female zebrafish were fed diets with 12.5 or 25 mu g T4/g body weight/day for five days, while controls received vehicle-only food. Plasma TH levels were measured, and females were bred with untreated males. Embryos and larvae were assessed from 0 to 144 h post-fertilization for survival, heartbeat, morphology, T3 content, and gene expression. Elevated maternal T4 increased embryonic T3, causing growth retardation, edema, spinal deformities, tachycardia, and mortality. Gene expression analysis revealed dysregulation of TH axis components and somatotropic genes, highlighting the maternal THs' critical role in developmental trajectories and normal growth.

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