Development of a UPLC-MS/MS-based method for simultaneous determination of advanced glycation end products and heterocyclic amines in stewed meat products
文献类型： 外文期刊
作者： Wang, Tan 1 ; Dong, Maofeng 2 ; Shen, Qinyi 2 ; Wen, Guangyue 2 ; Wang, Mingfu 3 ; Zhao, Yueliang 1 ;
作者机构： 1.Shanghai Ocean Univ, Coll Food Sci & Technol, Shanghai 201306, Peoples R China
2.Shanghai Acad Agr Sci, Inst Agrofood Stand & Testing Technol, Key Lab Safety Assessment Environm Agr Genet Modif, Pesticide Safety Evaluat Res Ctr,Minist Agr & Rura, Shanghai 201306, Peoples R China
3.Shenzhen Univ, Inst Adv Study, Shenzhen Key Lab Marine Microbiome Engn, Shenzhen, Peoples R China
4.Shanghai Jiao Tong Univ, Sch Med, Sch Publ Hlth, Shanghai, Peoples R China
5.Shenzhen Univ, Inst Adv Study, Shenzhen, Peoples R China
关键词： AGEs; HAs; UPLC-MS/MS; Stewed meat products
期刊名称：FOOD CHEMISTRY （ 影响因子：8.8； 五年影响因子：8.6 ）
ISSN： 0308-8146
年卷期： 2024 年 451 卷
页码：
收录情况： SCI
摘要： A novel analytical strategy was proposed to simultaneously quantify two advanced glycation end products (AGEs) including N-epsilon-(Carboxymethyl)lysine (CML), N-epsilon-(Carboxyethyl)lysine (CEL) and eight heterocyclic amines (HAs) including IQ, MeIQ, MeIQx, 4,8-DiMeIQx, 7,8-DiMeIQx, PhIP, Harman, and Norharman. The procedure was based on a two-step extraction, solid phase extraction (SPE) purification followed by ultra performance liquid chromatography tandem mass spectrometry. The established method showed a good linearity (R-2 >= 0.9950), rapid processing time (8 min per sample), satisfactory recoveries (matrix spiked recoveries range from 72.2% to 119.6%) and precision (intra-day and inter-day RSDs were <19.3%). The limit of quantification (LOQ) and limit of detection (LOD) resulted to be between 0.05-15 ng/g and 0.2-50 ng/g, respectively. The validated technique was further applied to determine HAs and AGEs in eight stewed meat product samples consumed in Shanghai, with the amount of HAs and AGEs ranging from 2.851 to 18.289 ng/g and 118.158-543.493 ng/g, respectively.
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