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Thiolated chitosan encapsulation constituted mucoadhesive nanovaccine confers broad protection against divergent influenza A viruses

文献类型： 外文期刊

作者： Ding, Peiyang 1 ; Liu, Hongliang 1 ; Zhu, Xifang 1 ; Chen, Yumei 1 ; Zhou, Jingming 1 ; Chai, Shujun 4 ; Wang, Aiping 1 ; Zhang, Gaiping 1 ;

作者机构： 1.Zhengzhou Univ, Sch Life Sci, Zhengzhou 450001, Peoples R China

2.Longhu Lab Adv Immunol, Zhengzhou 450046, Peoples R China

3.Henan Key Lab Immunobiol, Zhengzhou 450001, Peoples R China

4.Henan Acad Agr Sci, Henan Prov Key Lab Anim Immunol, Zhengzhou 450002, Peoples R China

5.Peking Univ, Sch Adv Agr Sci, Beijing 100080, Peoples R China

关键词： Mucoadhesive; Thiolated chitosan; Influenza nanovaccine; M2e; Nucleoprotein

期刊名称：CARBOHYDRATE POLYMERS （ 影响因子：11.2； 五年影响因子：10.2 ）

ISSN： 0144-8617

年卷期： 2024 年 328 卷

页码：

收录情况： SCI

摘要： Influenza A virus (IAV) poses a significant threat to human and animal health, necessitating the development of universal influenza vaccines that can effectively activate mucosal immunity. Intranasal immunization has attracted significant attention due to its capacity to induce triple immune responses, including mucosal secretory IgA. However, inducing mucosal immunity through vaccination is challenging due to the self-cleansing nature of the mucosal surface. Thiolated chitosan (TCS) were explored for mucosal vaccine delivery, capitalizing on biocompatibility and bioadhesive properties of chitosan, with thiol modification enhancing mucoadhesive capability. The focus was on developing a universal nanovaccine by utilizing TCS-encapsulated virus-like particles displaying conserved B-cell and T-cell epitopes from M2e and NP proteins of IAV. The optimal conditions for nanoparticle formation were investigated by adjusting the thiol groups content of TCS and the amount of sodium tripolyphosphate. The nanovaccine induced robust immune responses and provided complete protection against IAVs from different species following intranasal immunization. The broad protective effect of nanovaccines can be attributed to the synergistic effect of antibodies and T cells. This study developed a universal intranasal nanovaccine and demonstrated the potential of TCS in the development of mucosal vaccines for respiratory infectious diseases.

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