您好，欢迎访问上海市农业科学院 机构知识库！
上海市农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Structural Elucidation and Anti-Tumor Activity of a Polysaccharide (CP2-S) from Cordyceps militaris Fruit Bodies

文献类型： 外文期刊

作者： Zhu, Lina 1 ; Wang, Jinyan 1 ; Tang, Qingjiu 1 ; Liu, Yanfang 1 ;

作者机构： 1.Shanghai Acad Agr Sci, Inst Edible Fungi, Shanghai 201403, Peoples R China

2.Shanghai Jiao Tong Univ, Sch Agr & Biol, Shanghai 200240, Peoples R China

关键词： Cordyceps militaris; polysaccharide; structure; anti-tumor

期刊名称：POLYMERS （ 影响因子：4.7； 五年影响因子：4.9 ）

ISSN：

年卷期： 2024 年 16 卷 14 期

页码：

收录情况： SCI

摘要： A polysaccharide (CP2-S), consisting of glucose with a weight average molecular weight of 5.9 x 10(6), was purified from the fruit bodies of Cordyceps militaris. In this work, the corresponding structure and anti-tumor activity in vivo were investigated. Methylation and NMR analysis revealed that CP2-S was composed of a -> 4)-alpha-D-Glcp-(1 -> backbone with partial substitution occurring at O-6 by T-linked alpha-D-Glcp in every ten residues, which has not been reported in previous reports. In vivo anti-tumor experiments showed that CP2-S could inhibit the growth of Lewis lung carcinoma in mice. Tumor inhibition rates were 17.8%, 24.5%, and 29.5% at dosages of 12.5, 50, and 100 mg/kg/d, respectively. Compared with the cisplatin group, mice treated with CP2-S exhibited a significant increase in spleen index (increased 22.7-42.4%) and thymus index (increased 47.7-36.8%). Additionally, serum levels of IgM and IgG in tumor-bearing mice increased by approximately 6.11 similar to 10.75-folds and 1.31 similar to 1.38-folds, respectively. These findings prove that CP2-S significantly inhibited the growth of Lewis lung carcinoma through immune-enhancing activity in mice.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：上海市农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台