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Mefentrifluconazole exposure disrupted hepatic lipid metabolism disorder tightly associated with gut barrier function abnormal in mice

文献类型： 外文期刊

作者： Zhang, Hu 1 ; Wang, Juntao 2 ; Qian, Mingrong 3 ; Jin, Yuanxiang 2 ;

作者机构： 1.Zhejiang Acad Agr Sci, Inst Agroprod Safety & Nutr, Zhejiang Prov Key Lab Food Safety, Hangzhou 310021, Peoples R China

2.Zhejiang Univ Technol, Coll Biotechnol & Bioengn, Hangzhou 310032, Peoples R China

3.Zhejiang Shuren Univ, Interdisciplinary Res Acad, Key Lab Pollut Exposure & Hlth Intervent Zhejiang, Hangzhou 310015, Peoples R China

4.Zhejiang Shuren Univ, Interdisciplinary Res Acad, 8 Shuren St, Hangzhou 310015, Peoples R China

5.Zhejiang Univ Technol, Coll Biotechnol & Bioengn, 18 Chaowang Rd, Hangzhou 310014, Peoples R China

关键词： Mefentrifluconazole (MFZ); Mice; Lipid metabolism; Gut barrier function; Gut microbiota

期刊名称：SCIENCE OF THE TOTAL ENVIRONMENT （ 影响因子：9.8； 五年影响因子：9.6 ）

ISSN： 0048-9697

年卷期： 2023 年 905 卷

页码：

收录情况： SCI

摘要： Mefentrifluconazole (MFZ) is an azole fungicide that is placed in agriculture for the control of fungal hazards. However, due to their non-biodegradability, azole fungicides can accumulate in plants, animals, and the environment, thus becoming a major health concern worldwide. In this study, we exposed 7-week-old C57BL/6 mice to 10, 30, and 100 mg/kg of MFZ for 28 d to assess the toxic effects of MFZ on the liver and gut tissues of the mice. Histopathological, biochemical indexes, and transcriptomic analyses revealed that MFZ exposure disrupted the liver structure and hepatic lipid metabolism as well as damaged gut barrier function and promoted inflammation in mice. Moreover, 16S rRNA sequencing demonstrated that MFZ exposure significantly increased the abundance of patescibacteria at the generic level. Also, MFZ exposure increased the abundance of bacterial genera associated with inhibition of glycolipid metabolism. These results suggested that the disruption of liver lipid metabolism caused by MFZ exposure may be caused by changes in gut microbiota function. This study provided a new disease occurrence study for risk assessment of MFZ and strengthened the focus on some novel fungicides.

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