文献类型： 外文期刊
作者： Wang, Xuanpeng 1 ; Wang, Lili 1 ; Huang, Yongchi 1 ; Deng, Zhiping 3 ; Li, Cunliang 1 ; Zhang, Jian 1 ; Zheng, Mingxi 1 ; Yan, Shunping 1 ;
作者机构： 1.Hubei Hongshan Lab, Wuhan 430070, Peoples R China
2.Huazhong Agr Univ, Coll Life Sci & Technol, Wuhan 430070, Peoples R China
3.Zhejiang Acad Agr Sci, Inst Virol & Biotechnol, State Key Lab Managing Biot & Chem Threats Qual, Hangzhou 310021, Peoples R China
关键词： DNA damage response; homologous recombination repair; ubiquitination; SOG1
期刊名称：PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA （ 影响因子：12.779； 五年影响因子：13.45 ）
ISSN： 0027-8424
年卷期： 2022 年 119 卷 16 期
页码：
收录情况： SCI
摘要： Homologous recombination repair (HR) is an error-free DNA damage repair pathway to maintain genome stability and a basis of gene targeting using genome-editing tools. However, the mechanisms of HR in plants are still poorly understood. Through genetic screens for DNA damage response mutants (DDRM) in Arabidopsis, we find that a plant-specific ubiquitin E3 ligase DDRM1 is required for HR. DDRM1 contains an N-terminal BRCT (BRCA1 C-terminal) domain and a C-terminal RING (really interesting new gene) domain and is highly conserved in plants including mosses. The ddrm1 mutant is defective in HR and thus is hypersensitive to DNA-damaging reagents. Biochemical studies reveal that DDRM1 interacts with and ubiquitinates the transcription factor SOG1, a plant-specific master regulator of DNA damage responses. Interestingly, DDRM1-mediated ubiquitination promotes the stability of SOG1. Consistently, genetic data support that SOG1 functions downstream of DDRM1. Our study reveals that DDRM1-SOG1 is a plant-specific module for HR and highlights the importance of ubiquitination in HR.
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