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Arctium lappa L. roots inhibit the intestinal inflammation of dietary obese rats through TLR4/NF-κB pathway

文献类型： 外文期刊

作者： Zeng, Feng 1 ; Li, Ying 2 ; Zhang, Xiaoxiao 2 ; Feng, Jin 2 ; Gu, Wen 3 ; Shen, Li 1 ; Huang, Wuyang 1 ;

作者机构： 1.Yangzhou Univ, Med Coll, Jiangsu Key Lab Integrated Tradit Chinese & Wester, Yangzhou 225000, Peoples R China

2.Jiangsu Acad Agr Sci, Inst Agroprod Proc, Nanjing 210014, Peoples R China

3.Nanjing Forestry Univ, Coll Chem Engn, Jiangsu Coinnovat Ctr Efficient Proc & Utilizat Fo, Nanjing 210037, Peoples R China

4.Jiangsu Univ, Sch Food & Bioengn, Zhenjiang 212013, Peoples R China

5.Yangzhou Univ, Med Coll, Yangzhou 225000, Peoples R China

关键词： Burdock; Anti-obesity; Anti-inflammation; Intestinal tract; Toll-like receptor 4; Pro-inflammatory and inflammatory cytokines

期刊名称：HELIYON （ 影响因子：4.0； 五年影响因子：4.1 ）

ISSN：

年卷期： 2023 年 9 卷 11 期

页码：

收录情况： SCI

摘要： Long-term consumption of Arctium lappa L. roots can lead to weight loss. To explore the rela-tionship between anti-obesity and anti-inflammation, the effects and mechanism of A. lappa L. root powder (ARP) on intestinal inflammation in obese rats were investigated. Dietary obese rats were successfully established by feeding a high-fat and high-sugar diet. The control group (n = 6) consumed a normal diet. The intestines were compared among the groups (each n = 6) with and without the administration of ARP (intragastric 7.5 g/kg & sdot;bw/d). Real-time quantitative reverse transcription-polymerase chain reaction and western blotting analysis revealed that ARP effec-tively inhibited the expression of pro-inflammatory and inflammatory cytokines in the colons of obese rats. These cytokines included interleukin (IL)-1 beta, IL-8, IL-6, tumor necrosis factor-alpha (TNF-alpha), monocyte chemoattractant protein-1, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1. The inhibition rates for all these cytokines exceeded 88 %. Moreover, ARP demonstrated the ability to down-regulate key genes involved in Toll-like receptor 4 (TLR4) complexes, namely Tlr4, myeloid differentiation protein-2 (Md2), and myeloid differentiation factor 88 (Myd88), along with downstream signaling molecules such as tumor necrosis factor receptor associated factor 6 (TRAF6) and nuclear factor-kappa B (NF-kappa B), with inhibition rates over 81 %. Additionally, ARP was observed to inhibit protein levels of TLR4, NF-kappa B, IL-1 beta, and TNF-alpha in the colons of obese rats, with inhibition rates of 65.6 +/- 10.9 %, 84.4 +/- 19.9 %, 80.8 +/- 14.4 %, and 68.4 +/- 17.5 %, respectively. This study confirmed the effectiveness of ARP in inhibiting intestinal inflammation through the blockade of the TLR4/NF-kappa B signaling pathway. It also suggested that ARP holds potential in improving intestinal health in the context of obesity, implying its possible application in the prevention and treatment of obesity and related metabolic diseases.

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