Protective effects of paeonol against lipopolysaccharide-induced liver oxidative stress and inflammation in gibel carp (Carassius auratus gibelio)
文献类型： 外文期刊
作者： Gu, Yipeng 1 ; Chen, Kai 2 ; Xi, Bingwen 1 ; Xie, Jun 1 ; Bing, Xuwen 2 ;
作者机构： 1.Nanjing Agr Univ, Wuxi Fisheries Coll, Shanshui East Rd 9, Wuxi 214081, Jiangsu, Peoples R China
2.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Key Lab Freshwater Fisheries & Germplasm Resource, Minist Agr & Rural Affairs, Wuxi 214081, Jiangsu, Peoples R China
关键词： Paeonol; Carassius auratus gibelio; Lipopolysaccharide; Oxidative stress; Inflammation
期刊名称：COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY （ 影响因子：4.52； 五年影响因子：4.203 ）
ISSN： 1532-0456
年卷期： 2022 年 257 卷
页码：
收录情况： SCI
摘要： Paeonol (2'-hydroxy-4'-methoxyacetophenone) is a phenol that exhibits antioxidant and anti-inflammatory capabilities. In this study, the underlying mechanism of paeonol against LPS-induced oxidative stress and inflammatory responses in gibel carp was investigated. Three hundred healthy gibel carp were divided into five groups (n = 9), intraperitoneally injected with LPS and thereafter treated with paeonol (16 mg/kg and 64 mg/kg). Fish were anesthetized with MS-222 (100 mg/L), and samples were collected at 72 h to investigate plasma biochemical indexes, liver histopathology, antioxidant enzymatic activity, and TLR receptor-related gene expression. Fish injected with LPS (20 mg/kg) exhibited significantly increased plasma aminotransferase (ALT), aminotransferase (AST), lactate dehydrogenase (LDH), glucose (GLU), diamine oxidase (DAO), and alkaline phosphatase (ALP) levels (P < 0.05). In addition, LPS challenge significantly enhanced myeloperoxidase (MPO) and malondialdehyde (MDA) contents, whereas those of catalase (CAT) and glutathione peroxidase (GSH-Px) decreased (P < 0.05). However, treatment with paeonol attenuated these LPS-induced changes (P < 0.05). The mRNA expression of TLR4, TIRAP, MyD88, TRAF6, NF-kappa B, TNF-alpha, IL-1 beta, and IL-8, which were activated by LPS challenge (P < 0.05), were downregulated by paeonol. Additionally, histopathological examination demonstrated that paeonol alleviates LPS-induced hepatic tissue lesions in fish. Taken together, the results suggest that paeonol mitigates LPS-induced liver oxidative stress and inflammation in gibel carp.
- 相关文献
作者其他论文 更多>>
-
Integration of transcriptome, histopathology, and physiological indicators reveals regulatory mechanisms of largemouth bass ( Micropterus salmoides) in response to carbonate alkalinity stress
作者：Hua, Jixiang;Xi, Bingwen;Qiang, Jun;Hua, Jixiang;Tao, Yifan;Lu, Siqi;Li, Yan;Dong, Yalun;Jiang, Bingjie;Xi, Bingwen;Qiang, Jun
关键词：Micropterus salmoides; Carbonate alkalinity stress; Tissue damage; Serum biological chemistry; RNA-seq
-
Muscle quality enhancement of largemouth bass (Micropterus salmoides) by alkaline water cultured environment: A comprehensive evaluation of physical features, nutrient composition, and flavor characteristics
作者：Hua, Jixiang;Jiao, Xidong;Wang, Wen;Xi, Bingwen;Qiang, Jun;Hua, Jixiang;Tao, Yifan;Lu, Siqi;Dong, Yalun;Wang, Wen;Xi, Bingwen;Qiang, Jun;Jiao, Xidong;Fan, Daming
关键词：Micropterus salmoides; Alkaline water culture; Muscle quality; Nutrient composition; GC-IMS; Volatile compounds
-
C4-HSL drives rapid biofilm formation in low-temperature aquaculture effluent: strengthening structural stability of biofilm and improving nitrogen removal efficiency
作者：Li, Junlin;Ma, Jiahao;Li, Zhifei;Xie, Jun;Zhang, Yuting;Yu, Mengyuan;Xia, Yun;Gong, Wangbao;Zhang, Kai;Wang, Guangjun;Zhong, Quanfa;Tian, Jingjing;Li, Hongyan;Xie, Wenping;Li, Junlin;Li, Junlin;Ma, Jiahao;Li, Zhifei;Xie, Jun;Zhang, Yuting;Yu, Mengyuan;Xia, Yun;Gong, Wangbao;Zhang, Kai;Wang, Guangjun;Zhong, Quanfa;Tian, Jingjing;Li, Hongyan;Xie, Wenping
关键词：Quorum sensing; Biofilm; Aquaculture; Nitrogen metabolism
-
Gill and brain transcriptomic analysis of mandarin fish(Siniperca chuatsi) reveals hypoxia-induced mitochondrial dysfunction and modulation of metabolism
作者：Ding, Weidong;Cao, Liping;Cao, Zheming;Bing, Xuwen
关键词：Mandarin fish; Transcriptome; Hypoxia; DEGs
-
The Naturally Bioactive Vicine Extracted from Faba Beans Is Responsible for the Transformation of Grass Carp (Ctenopharyngodon idella) into Crisp Grass Carp
作者：Tian, Jingjing;Xie, Jun;Yu, Ermeng;Zheng, Xinyu;Hou, Jilun;Zheng, Xinyu;Hou, Jilun;Zheng, Xinyu;Hou, Jilun;Yu, Ermeng;Kaneko, Gen;Fu, Bing;Luo, Minyi
关键词：reactive oxygen species; oxidant stress; vicine; grass carp; textural quality
-
Optimal selection of machine learning algorithms for ciprofloxacin prediction based on conventional water quality indicators
作者：Jiang, Shenqiong;Cheng, Xiangju;Shi, Baoshan;Zhu, Dantong;Cheng, Xiangju;Shi, Baoshan;Zhu, Dantong;Xie, Jun;Zhou, Zhihong
关键词：Machine learning model; Water quality prediction; Optimization algorithms; Sensitivity analysis; Ciprofloxacin
-
Effects of berberine combined with Pennisetum sinese Roxb meal on growth, hepatic lipid metabolism, and intestinal health of grass carp, Ctenopharyngodon idella
作者：Tian, Jingjing;Wang, Binbin;Ji, Mengmeng;Gong, Wangbao;Li, Hongyan;Xia, Yun;Zhang, Kai;Li, Zhifei;Xie, Wenping;Wang, Guangjun;Xie, Jun
关键词：Eco-friendly feed; Entero-hepatic health; Sustainable aquaculture; Chinese herbal medicine; High-density intensive aquaculture
