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Phylogenetic Grouping and Antimicrobial Resistance Profiles of Escherichia coli Isolated from Calves in Xinjiang, China

文献类型： 外文期刊

作者： Zhang, Xingxing 1 ; Li, Jie 1 ; Zhang, Ling 3 ; Qiao, Jun 1 ; Meng, Qingling 1 ; Chen, Ying 4 ; Cai, Kuojun 5 ; Huang, Xi 1 ;

作者机构： 1.Shihezi Univ, Coll Anim Sci & Technol, Shihezi 832003, Xinjiang, Peoples R China

2.Xinjiang Acad Agr & Reclamat Sci, State Key Lab Sheep Genet Improvement & Hlth Prod, Shihezi 832000, Xinjiang, Peoples R China

3.Tarim Univ, Coll Anim Sci & Technol, Alar 843300, Xinjiang, Peoples R China

4.Xinjiang Agr Vocat & Tech Coll, Coll Anim Sci & Technol, Changji 31100, Xinjiang, Peoples R China

5.Urumqi Anim Dis Control & Diag Ctr, Urumqi 830063, Xinjiang, Peoples R China

关键词： Escherichia coli; Phylogenetic grouping; Antimicrobial resistance; Resistance genes; Calf

期刊名称：KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI （ 影响因子：0.685； 五年影响因子：0.655 ）

ISSN： 1300-6045

年卷期： 2020 年 26 卷 3 期

页码：

收录情况： SCI

摘要： The widespread multidrug-resistant Escherichia coli strains have caused a severe challenge to animal health and the development of breeding industries. The purpose of this study was to investigate the phylogenetic grouping and antimicrobial resistance profiles of E. coli isolated from diarrheic calves in Xinjiang province, China. In this study, a total of 379 E. coli strains were isolated from 379 rectal swab samples of diarrheic calves. They were further analyzed their phylogenetic groupings by multiplex PCR, and were clustered into four phylogenetic groups, A (36.1%), B1 (17.4%), B2 (15.6%), and D (30.9%). All E. coli isolates were tested for their susceptibility to 15 antimicrobial agents by Kirby-Bauer (KB) method. The isolates showed the highest resistance rates against ampicillin (64.9%), followed by streptomycin (59.4%), tetracycline (53.8%), sulfamethoxazole/ trimethoprim (50.9%), chloramphenicol (45.6%), kanamycin (44.1%) and enrofloxacin (42.0%). E. coli isolates exhibited lower resistance to ceftazidime (15.0%) and polymyxin (12.6%). The resistance genes blaTEM blaOXA, mcr-1, strA-strB, aadA, tet(A), tet(B), and tet(C) were detected in 68.3% (168/246), 27.2% (67/246), 14.6% (7/48), 51.1% (115/225), 24.9% (56/225), 51.5% (105/204), 44.6% (91/204), and 7.8% (16/204) of E. coli isolates, respectively. These results demonstrate that prevalent multi-drug resistance and high level of antimicrobial resistance genes exist among E. con from Xinjiang diarrheic calves and pose a potential public health concern.

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