In-ovo Newcastle disease virus vaccine strain TS09-C protects commercial chickens against Newcastle disease in the presence of maternally derived antibodies
文献类型： 外文期刊
作者： Fan, Sanling 1 ; Wu, Yulun 1 ; Wang, Hongling 1 ; Shang, Yu 1 ; Luo, Qingping 1 ; Zhang, Tengfei 1 ; Zhang, Rongrong 1 ;
作者机构： 1.Hubei Acad Agr Sci, Inst Anim Husb & Vet Sci, Wuhan, Peoples R China
2.Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Wuhan, Peoples R China
3.Minist Agr, Key Lab Prevent & Control Agents Anim Bacteriosis, Wuhan, Peoples R China
4.Hubei Key Lab Anim Embryo & Mol Breeding, Wuhan, Peoples R China
关键词： Newcastle disease virus; in-ovo vaccine; maternally derived antibody; strain TS09-C
期刊名称：POULTRY SCIENCE （ 影响因子：3.352； 五年影响因子：3.679 ）
ISSN：
年卷期： 2020 年 99 卷 5 期
页码：
收录情况： SCI
摘要： Maternally derived antibodies (MDA) substantially interfere with active immunity in posthatch vaccination, although they provide early protection against disease through passive immunity in young chickens. Previously, Newcastle disease virus (NDV) strain TS09-C was demonstrated to be safe and immunogenic as in-ovo vaccine in specific-pathogen-free chickens. Here, we evaluated the safety, protective efficacy, and duration of clinical protection of the TS09-C virus as an in-ovo vaccine for commercial chickens in the presence of Maternally derived antibodies against NDV. This vaccine was safe in commercial chickens and provided at least 80% protection against a virulent NDV challenge for 3 mo, despite inducing a low hemagglutinin-inhibition titer. For commercial chickens, the protective efficacy of the in-ovo vaccination was markedly higher than that of posthatch vaccination, and the cellular immune response might play an important role in the higher protective efficacy of the in-ovo vaccine. The overall results indicate that the maternally derived antibodies against NDV do not significantly interfere with the ability of the in-ovo vaccine strain TS09-C to induce protective cellular immunity.
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