Molecular characterization and function of EGFR during viral infectionprocess in Mandarin fishSiniperca chuatsi
文献类型： 外文期刊
作者： Niu, Yinjie 1 ; Fu, Xiaozhe 1 ; Liu, Lihui 1 ; Lin, Qiang 1 ; Liang, Hongru 1 ; Huang, Zhibin 1 ; Li, Ningqiu 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Pearl River Fisheries Res Inst, Key Lab Fishery Drug Dev, Key Lab Aquat Anim Immune Technol,Minist Agr & Ru, Guangzhou 510380, Guangdong, Peoples R China
关键词： Mandarin fish; Epidermal growth factor receptor; ISKNV; SCRV
期刊名称：FISH & SHELLFISH IMMUNOLOGY （ 影响因子：4.581； 五年影响因子：4.851 ）
ISSN： 1050-4648
年卷期： 2020 年 102 卷
页码：
收录情况： SCI
摘要： Epidermal growth factor receptor (EGFR) is a tyrosine kinase protein and plays a critical role in virus infection by modulating innate immunity. In this study, we cloned and sequenced the EGFR coding sequence of mandarin fish, designed as scEGFR, and explored its characteristics. scEGFR mRNA was widely expressed in the tested tissues of mandarin fish, and the higher mRNA levels were expressed in kidney and spleen. scEGFR expression was up-regulated in spleen and CPB cells at early stage of ISKNV and SCRV infection. Gefitinib (EGFR inhibitor) inhibited ISKNV and SCRV replication, and increased the expression of the interferon-stimulated genes (ISG). However the EGF (EGFR activator) promoted ISKNV and SCRV replication, and decreased the interferon-stimulated genes. Those results indicated that scEGFR and its signaling involved in ISKNV and SCRV infection, and EGFR activation negatively regulated the interferon response, providing a potential target for the development of new therapic strategy against ISKNV and SCRV.
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