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Are pangolins the intermediate host of the 2019 novel coronavirus (SARS-CoV-2)?

文献类型： 外文期刊

作者： Liu, Ping 1 ; Jiang, Jing-Zhe 2 ; Wan, Xiu-Feng 3 ; Hua, Yan 8 ; Li, Linmiao 1 ; Zhou, Jiabin 1 ; Wang, Xiaohu 9 ; Hou, F 1 ;

作者机构： 1.Guangdong Acad Sci, Guangdong Inst Appl Biol Resources, Guangdong Key Lab Anim Conservat & Resource Utili, Guangdong Publ Lab Wild Anim Conservat & Utilizat, Guangzhou, Guangdong, Peoples R China

2.Chinese Acad Fishery Sci, South China Sea Fisheries Res Inst, Key Lab South China Sea Fishery Resources Exploit, Minist Agr, Guangzhou, Guangdong, Peoples R China

3.Univ Missouri, Sch Med, Dept Mol Microbiol & Immunol, Columbia, MO 65212 USA

4.Univ Missouri, Coll Engn, Dept Elect Engn & Comp Sci, Columbia, MO USA

5.Univ Missouri, MU Ctr Res Influenza Syst Biol CRISB, Columbia, MO USA

6.Univ Missouri, Bond Life Sci Ctr, Columbia, MO USA

7.Univ Missouri, MU Inst Data Sci & Informat, Columbia, MO USA

8.Guangdong Acad Forestry, Guangdong Prov Key Lab Silviculture Protect & Uti, Guangzhou, Guangdong, Peoples R China

9.Guangdong Acad Agr Sci, Inst Anim Hlth, Guangzhou, Guangdong, Peoples R China

10.Guangdong Prov Wildlife Rescue Ctr, Guangzhou, Guangdong, Peoples R China

期刊名称：PLOS PATHOGENS （ 影响因子：6.823； 五年影响因子：7.455 ）

ISSN： 1553-7366

年卷期： 2020 年 16 卷 5 期

页码：

收录情况： SCI

摘要： The outbreak of a novel corona Virus Disease 2019 (COVID-19) in the city of Wuhan, China has resulted in more than 1.7 million laboratory confirmed cases all over the world. Recent studies showed that SARS-CoV-2 was likely originated from bats, but its intermediate hosts are still largely unknown. In this study, we assembled the complete genome of a coronavirus identified in 3 sick Malayan pangolins. The molecular and phylogenetic analyses showed that this pangolin coronavirus (pangolin-CoV-2020) is genetically related to the SARS-CoV-2 as well as a group of bat coronaviruses but do not support the SARS-CoV-2 emerged directly from the pangolin-CoV-2020. Our study suggests that pangolins are natural hosts of Betacoronaviruses. Large surveillance of coronaviruses in pangolins could improve our understanding of the spectrum of coronaviruses in pangolins. In addition to conservation of wildlife, minimizing the exposures of humans to wildlife will be important to reduce the spillover risks of coronaviruses from wild animals to humans. Author summary Recently, a novel coronavirus, SARS-CoV-2, caused a still ongoing pandemic. Epidemiological study suggested this virus was associated with a wet market in Wuhan, China. However, the exact source of this virus is still unknown. In this study, we attempted to assemble the complete genome of a coronavirus identified from two groups of sick Malayan pangolins, which were likely to be smuggled for black market trade. The molecular and evolutionary analyses showed that this pangolin coronavirus we assembled was genetically associated with the SARS-CoV-2 but was not likely its precursor. This study suggested that pangolins are natural hosts of coronaviruses. Determining the spectrum of coronaviruses in pangolins can help understand the natural history of coronaviruses in wildlife and at the animal-human interface, and facilitate the prevention and control of coronavirus-associated emerging diseases.

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