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Toxicological effects of nano- and micro-polystyrene plastics on red tilapia: Are larger plastic particles more harmless?

文献类型： 外文期刊

作者： Ding, Jiannan 1 ; Huang, Yejing 1 ; Liu, Shujiao 1 ; Zhang, Shanshan 1 ; Zou, Hua 1 ; Wang, Zhenyu 1 ; Zhu, Wenbin 4 ; Ge 1 ;

作者机构： 1.Jiangnan Univ, Sch Environm & Civil Engn, Wuxi 214122, Jiangsu, Peoples R China

2.Jiangsu Collaborat Innovat Ctr Technol & Mat Wate, Suzhou 215009, Peoples R China

3.Biomass Energy & Biol Carbon Reduct Engn Ctr Jian, Wuxi 214122, Jiangsu, Peoples R China

4.Chinese Acad Fishery Sci, Key Lab Freshwater Fisheries & Germplasm Resource, Minist Agr, Freshwater Fisheries Res Ctr, Wuxi 214081, Jiangsu, Peoples R China

5.Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Peoples R China

关键词： Freshwater; Size; Accumulation; Metabolomics; Integrated biomarker response

期刊名称：JOURNAL OF HAZARDOUS MATERIALS （ 影响因子：10.588； 五年影响因子：10.129 ）

ISSN： 0304-3894

年卷期： 2020 年 396 卷

页码：

收录情况： SCI

摘要： Nanoplastics (NPs) and microplastics (MPs) are a heterogeneous class of pollutants with diverse sizes in aquatic environments. To evaluate the hazardous effects of N/MPs with different sizes, the accumulation, oxidative stress, cytochrome P450 (CYP) enzymes, neurotoxicity, and metabolomics changes were investigated in the red tilapia exposed to three sizes of polystyrene (PS) N/MPs (0.3, 5, and 70 - 90 mu m). After 14-d exposures, the largest particles (70 - 90 mu m) showed the highest accumulation levels in most cases. Exposures to PS-MPs (5 and 70 - 90 mu m) caused a more severe oxidative stress in red tilapia than PS-NPs. The activity of CYP3A-related enzyme was obviously inhibited by PS-NPs, whereas the CYP enzymes in the liver may not be sensitive to MP exposures. In the brain, only 5 mu m PS-MPs significantly inhibited the acetylcholinesterase activity. After exposures, the treatments with 0.3, 5, and 70 - 90 mu m N/MPs resulted in 31, 40, and 23 significantly differentially expressed metabolites, respectively, in which the pathway of tyrosine metabolism was significantly affected by all the three PS-N/MP exposures. Overall, the PS particles within the pm size posed more severe stress to red tilapia. Our results suggest that the toxicity of N/MPs may not show a simply monotonic negative correlation with their sizes.

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