您好，欢迎访问新疆农垦科学院 机构知识库！
新疆农垦科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Genome-Wide Detection of CNVs and Association With Body Weight in Sheep Based on 600K SNP Arrays

文献类型： 外文期刊

作者： Wang, Zhipeng 1 ; Guo, Jing 1 ; Guo, Yuanyuan 1 ; Yang, Yonglin 3 ; Teng, Teng 4 ; Yu, Qian 3 ; Wang, Tao 1 ; Zhou, Meng; 1 ;

作者机构： 1.Northeast Agr Univ, Coll Anim Sci & Technol, Harbin, Peoples R China

2.Educ Dept Heilongjiang Prov, Key Lab Anim Genet Breeding & Reprod, Harbin, Peoples R China

3.Xinjiang Acad Agr & Reclamat Sci, State Key Lab Sheep Genet Improvement & Hlth Prod, Shihezi, Peoples R China

4.Northeast Agr Univ, Inst Anim Nutr, Harbin, Peoples R China

5.Shandong Agr Univ, Dept Anim Genet & Breeding, Coll Anim Sci & Technol, Tai An, Shandong, Peoples R China

关键词： body weight; copy number variation; sheep; SNP; breed-specific

期刊名称：FRONTIERS IN GENETICS （ 影响因子：4.599； 五年影响因子：4.888 ）

ISSN：

年卷期： 2020 年 11 卷

页码：

收录情况： SCI

摘要： Copy number variations (CNVs) are important genomic structural variations and can give rise to significant phenotypic diversity. Herein, we used high-density 600K SNP arrays to detect CNVs in two synthetic lines of sheep (DS and SHH) and in Hu sheep (a local Chinese breed). A total of 919 CNV regions (CNVRs) were detected with a total length of 48.17 Mb, accounting for 1.96% of the sheep genome. These CNVRs consisted of 730 gains, 102 losses, and 87 complex CNVRs. These CNVRs were significantly enriched in the segmental duplication (SD) region. A CNVR-based cluster analysis of the three breeds revealed that the DS and SHH breeds share a close genetic relationship. Functional analysis revealed that some genes in these CNVRs were also significantly enriched in the olfactory transduction pathway (oas04740), including members of the OR gene family such asOR6C76,OR4Q2, andOR4K14. Using association analyses and previous gene annotations, we determined that a subset of identified genes was likely to be associated with body weight, includingFOXF2,MAPK12,MAP3K11,STRBP, andC14orf132. Together, these results offer valuable information that will guide future efforts to explore the genetic basis for body weight in sheep.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：新疆农垦科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台