Hepatic oxidative stress,DNAdamage and apoptosis in adult zebrafish following sub-chronic exposure toBDE-47 andBDE-153
文献类型： 外文期刊
作者： Meng, Shunlong 1 ; Chen, Xi 1 ; Gyimah, Eric 3 ; Xu, Hai 3 ; Chen, Jiazhang 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Wuxi 214081, Jiangsu, Peoples R China
2.CAFS, Key Lab Fishery Ecoenvironm Assessment & Resource, Wuxi 214081, Jiangsu, Peoples R China
3.Jiangsu Univ, Sch Environm & Safety Engn, Xuefu Rd 301, Zhenjiang 212013, Jiangsu, Peoples R China
关键词： apoptosis-related genes; DNA damage; hepatocyte; oxidative stress; zebrafish
期刊名称：ENVIRONMENTAL TOXICOLOGY （ 影响因子：4.119； 五年影响因子：3.404 ）
ISSN： 1520-4081
年卷期： 2020 年 35 卷 11 期
页码：
收录情况： SCI
摘要： Polybrominated diphenyl ethers (PBDEs) are ubiquitous and prolific contaminant in both the abiotic and biotic environment because of the wide industrial applications of these chemicals. In the present study, the effects of 2,2 ',4,4 '-tetrabrominateddiphenyl ether (BDE-47) and 2,2 ',4,4 ',5,5 '-hexabromodiphenyl ether (BDE-153) exposure on the induction of hepatic oxidative stress, DNA damage, and the expression of apoptosis-related genes in adult zebrafish were investigated. The activities of antioxidant enzymes, such as catalase and superoxide dimutase, significantly increased when adult zebrafish was exposed to various concentrations of BDE-47 and BDE-153 for 7 and 15 days. BDE-47 and BDE-153 elicited significant alterations in zebrafish 7-Ethoxyresorufin-O-deethylase activity at 3, 7, or 15 days of exposure. In addition, the significant increase in comet assay parameters of zebrafish hepatocytes in a concentration-dependent manner indicated BDE-47 and BDE-153 induced DNA damage, probably due to observed oxidative stress. Furthermore, a monotonically upregulation ofp53andCaspase3, which are apoptotic-regulated genes, and decreased expression ratio of the anti-apoptotic B-cell lymphoma/leukaemia-2 and Bcl2-associated X protein genes for all BDE-47 and BDE-153 treatments at 7 and 15 days indicated apoptosis induction in zebrafish liver. Our findings help elucidate the mechanisms of BDE-47- and BDE-153-induced toxicity in zebrafish hepatocytes.
- 相关文献
作者其他论文 更多>>
-
Flux profile of selenium intake and dietary health assessment of tilapia products in China e-commerce platform
作者：Jing, Zhenyi;Guan, Ziqiang;Yin, Qianyue;Wang, Changbo;Fan, Limin;Meng, Shunlong;Song, Chao;Guan, Ziqiang;Fang, Longxiang;Yin, Qianyue;Wang, Changbo;Fan, Limin;Meng, Shunlong;Song, Chao;Fang, Longxiang;Wang, Changbo;Fan, Limin;Meng, Shunlong;Song, Chao;Fang, Longxiang;Wang, Changbo;Fan, Limin;Meng, Shunlong;Song, Chao;Fang, Longxiang;Wang, Changbo;Fan, Limin;Meng, Shunlong
关键词：Selenium; Tilapia; Sales Patterns; Product Forms; Dietary Health Impact Assessment
-
Magnetic nanoparticle modified moss Biochar: A novel solution for effective removal of enrofloxacin from aquaculture water
作者：Li, Zhonghua;Pitakrattanawong, Chompoonuch;Zhu, Lei;Fan, Limin;Song, Chao;Fang, Longxiang;Fan, Limin;Song, Chao;Meng, Shunlong;Fang, Longxiang;Fan, Limin;Song, Chao;Meng, Shunlong;Fang, Longxiang;Fan, Limin;Song, Chao;Meng, Shunlong;Fang, Longxiang;Fan, Limin;Song, Chao;Meng, Shunlong;Song, Chao;Meng, Shunlong
关键词：Resource recycling; Enrofloxacin; Magnetic biochar; Adsorption mechanism
-
Potential impact of marine-derived plastisphere as a Vibrio carrier on marine ecosystems: Current status and future perspectives
作者：Sun, Xuemei;Sui, Qi;Zhu, Lin;Yu, Yongxiang;Xia, Bin;Sun, Xuemei;Sui, Qi;Zhu, Lin;Xia, Bin;Booth, Andy M.;Meng, Shunlong;Xing, Baoshan
关键词：Microplastics; Biofilm; Vibrio; Mariculture; Biogeochemical cycling; Pathogen dispersal
-
N-Doping/KOH Synergy in Waste Moss Biochar for Geosmin Removal in Aquaculture Water: Elucidating Surface Functionalization and Activation Mechanisms
作者：Li, Zhonghua;Fan, Limin;Meng, Shunlong;Song, Chao;Chen, Xi;Qiu, Liping;Xu, Huimin;Fan, Limin;Meng, Shunlong;Song, Chao;Qiu, Liping;Xu, Huimin;Fan, Limin;Meng, Shunlong;Song, Chao;Qiu, Liping;Xu, Huimin;Fan, Limin;Meng, Shunlong;Song, Chao;Jiang, Zhongquan;Jiang, Zhongquan
关键词：earthy substance; aquaculture water remediation; N-doped biochar; alkali activation; bioresources recycling
-
Human activity driven spatial heterogeneity of pollutants in a highland river basin revealed by non-target screening and improved PBT evaluation: A case study from the Yalong River on the Qinghai-Tibet Plateau,China
作者：Ma, Zhiyuan;Meng, Shunlong;Gao, Xin;Zhu, Lei;Li, Zhonghua;Gao, Yuxiao;Song, Chao;Ma, Zhiyuan;Meng, Shunlong;Gao, Xin;Fang, Longxiang;Zhu, Lei;Li, Zhonghua;Gao, Yuxiao;Qiu, Liping;Song, Chao;Wan, Hui;Meng, Shunlong;Fang, Longxiang;Qiu, Liping;Song, Chao;Meng, Shunlong;Fang, Longxiang;Qiu, Liping;Song, Chao;Meng, Shunlong;Fang, Longxiang;Qiu, Liping;Song, Chao;Rong, Bo;Rong, Bo
关键词：Non-targeted screening; Improved PBT assessment; Highland river basin; Land use impact; Random forest-NMDS analysis
-
Cadmium Accumulation and Regulation in the Freshwater Mussel Anodonta woodiana
作者：Chen, Xiubao;Song, Chao;Jiang, Tao;Xue, Junren;Meng, Shunlong;Chen, Xiubao;Bah, Ibrahim;Gu, Mengying;Jiang, Jiazhen;Bah, Ibrahim;Wang, Meiyi
关键词：cadmium; stable isotope dual-tracer technique; Anodonta woodiana; bioaccumulation; transcriptome; molecular regulatory
-
The chromosomal-level genome assembly and annotation of pen shell Atrina pectinata
作者：Li, Zhuanzhuan;Chen, Xi;Ma, Peizhen;Liu, Zhihong;Sun, Xiujun;Zhou, Liqing;Wu, Biao;Li, Zhuanzhuan;Chen, Xi;Ma, Peizhen;Liu, Zhihong;Sun, Xiujun;Zhou, Liqing;Wu, Biao;Liu, Bo;Ren, Jianfeng;Zheng, Yanxin;Yu, Tao
关键词：
