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The transcriptomes from two adipocyte progenitor cell types provide insight into the differential functions of MSTN

文献类型： 外文期刊

作者： Deng, Bing 1 ; Zhang, Feng 2 ; Wen, Jianghui 4 ; Shen, Wenjun 5 ; Gao, Qishuang 1 ; Peng, Xia 1 ; Tan, Junjun 1 ; Pu, Zhe 1 ;

作者机构： 1.Wuhan Acad Agr Sci & Technol, Inst Anim Husb & Vet, Wuhan 430208, Hubei, Peoples R China

2.Huazhong Agr Univ, Key Lab Agr Anim Genet Breeding & Reprod, Key Lab Swine Genet & Breeding, Agr Minist,Minist Educ,Coll Anim Sci & Technol, Wuhan 430070, Peoples R China

3.Hubei Acad Agr Sci, Inst Anim Husb & Vet, Hubei Key Lab Anim Embryo Engn & Mol Breeding, Wuhan 430064, Peoples R China

4.Wuhan Univ Technol, Wuhan 430074, Peoples R China

5.Stanford Univ, Div Endocrinol Gerontol & Metab, Stanford, CA 94305 USA

6.Cooperat Innovat Ctr Sustainable Pig Prod, Wuhan 430070, Peoples R China

关键词： Porcine; Adipose-derived stem cells; Muscle satellite cells; Myostatin; Adipogenesis

期刊名称：GENOMICS （ 影响因子：5.736； 五年影响因子：4.939 ）

ISSN： 0888-7543

年卷期： 2020 年 112 卷 5 期

页码：

收录情况： SCI

摘要： Myostatin (MSTN) was previously shown to differentially regulate the adipogenesis of adipose-derived stem cells (ADSCs) and muscle satellite cells (MSCs), both of which can serve as progenitor cells for intramuscular adipocytes. We previously showed that MSTN mediates the differential regulation of MyoD and PPAR gamma in ADSCs and MSCs. Here, we analyzed the effects of MSTN on whole-transcriptome expression profiles of ADSCs and MSCs, revealing that MSTN differentially regulates ADSCs and MSCs, with MSCs being more responsive to MSTN treatment. More genes and pathways were altered in MSCs than in ADSCs. These changes may be responsible for the differences in the adipogenesis potential of ADSCs and MSCs after MSTN treatment. Analysis of the functions of genes that are differentially expressed in ADSCs and MSCs showed that KLF6 is a positive regulator of adipogenesis. In conclusion, the results provide important molecular insights into the regulatory mechanisms of MSTN in ADSCs and MSCs.

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