文献类型： 外文期刊
作者： Duan, Saixing 2 ; Liu, Xingyu 3 ; Liu, Wenjing 3 ; Dou, Yuting 3 ; Xu, Gaoxiao 2 ; Zhang, Feng 1 ; Geng, Kuan 4 ; Xiong, Qi 1 ; Chen, Mengjie 1 ;
作者机构： 1.Hubei Acad Agr Sci, Inst Anim Sci & Vet Med, Key Lab Anim Embryo Engn & Mol Breeding Hubei Prov, Wuhan 430064, Peoples R China
2.Fuyang Normal Univ, Sch Biol & Food Engn, Anhui Prov Key Lab Embryo Dev & Reprod Regulat, Anhui Prov Key Lab Environm Hormone & Reprod, Fuyang 236037, Peoples R China
3.Guangxi Univ, State Key Lab Conservat & Utilizat Subtrop Agrobio, Nanning 530000, Peoples R China
4.Henan Dairy Prod Performance Measurement Co Ltd, Zhengzhou 450003, Henan, Peoples R China
关键词： Enhancer; Promoter; Muscle; Buffalo; Transcriptions
期刊名称：GENOMICS （ 影响因子：3.0； 五年影响因子：3.3 ）
ISSN： 0888-7543
年卷期： 2025 年 117 卷 4 期
页码：
收录情况： SCI
摘要： The developmental process of skeletal muscle involves a wide variety of regulatory factors. However, little has been reported regarding the function and mechanisms of enhancer regulation in buffalo skeletal muscle growth and development. In this study, we discovered an enhancer that affects the buffalo skeletal muscle growth and development, which we named Enh67. Experimental results from CCK-8, EdU, qPCR, and Western blot assays indicated that Enh67 inhibits the proliferation of buffalo muscle stem cells. Immunofluorescence staining, qPCR, and Western blot results showed that Enh67 promotes the differentiation of buffalo muscle stem cells. Finally, we determined through 3C and qPCR assays that Enh67 targets CEP85L. Our findings not only enrich the regulatory factors involved in buffalo skeletal muscle growth and development but also provide potential target candidates for improving meat production and treating muscle development-related diseases in livestock.
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