Sturgeon protein-derived peptides exert anti-inflammatory effects in LPS-stimulated RAW264.7 macrophages via the MAPK pathway
文献类型： 外文期刊
作者： Gao, Ruichang 1 ; Shu, Wanghui 1 ; Shen, Yang 1 ; Sun, Quancai 1 ; Bai, Fan 3 ; Wang, Jinlin 3 ; Li, Dajing 4 ; Li, Ying; 1 ;
作者机构： 1.Jiangsu Univ, Sch Food & Biol Engn, 301 Xuefu Rd, Zhenjiang 212013, Jiangsu, Peoples R China
2.Shanxi Univ Technol, Sch Biosci & Engn, Bioresources Key Lab Shanxi Prov, Hanzhong 723001, Peoples R China
3.Quzhou Xunlong Aquat Prod Sci Tech Dev Co Ltd, Quzhou 324000, Peoples R China
4.Jiangsu Acad Agr Sci, Inst Agroprod Proc, Nanjing 210014, Jiangsu, Peoples R China
关键词： Sturgeon; Synthetic peptides; Anti-inflammatory effect; MAPK pathway; RAW264.7 macrophages
期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：4.451； 五年影响因子：4.907 ）
ISSN： 1756-4646
年卷期： 2020 年 72 卷
页码：
收录情况： SCI
摘要： Previous studies have demonstrated that polypeptides extracted from fish protein possess potential anti-inflammatory effects, but few studies have reported the underlying anti-inflammatory mechanism of sturgeon peptides. Hence, the goal of this study was to explore the peptide sequences with potential anti-inflammatory activity derived from sturgeon muscle protein in the lipopolysaccharide (LPS)-induced RAW264.7 inflammatory model. Fourteen novel peptides were identified in major muscle proteins by mass spectrometry, and three synthetic peptides - KIWHHTF, VHYAGTVDY, and HLDDALRGQE - decreased the release of inflammatory mediators and inflammatory cytokines (NO, IL-6, and IL-1 beta), while increasing SOD activity significantly in the LPS-induced RAW264.7 inflammatory model. Western blotting analysis revealed that these peptides suppressed the phosphorylation levels of MAPKs, indicating that these peptides exerted anti-inflammatory effects by inhibiting the MAPK pathway. The novel peptides potentially have application prospects as functional food ingredients.
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